血清孕酮联合子宫螺旋动脉血流检测对先兆流产妊娠结局的预测作用  

Predictive effect of serum progesterone combined with uterine spiral artery blood flow detection on pregnancy outcome in patients with threatened abortion

作　　者：穆晓荣 李玲俐[1] 

机构地区：[1]重庆市巴南区人民医院,401320

出　　处：《中国计划生育学杂志》2018年第3期202-205,共4页Chinese Journal of Family Planning

摘　　要：目的:观察血清孕酮检测联合子宫螺旋动脉血流超声检测对先兆流产患者妊娠结局的预测作用。方法:2015年8月-2017年8月本院就诊的400例孕早期女性为研究对象,其中正常妊娠产前检查200例(正常妊娠组),早期先兆流产保胎成功138例(保胎成功组),早期先兆流产保胎失败62例(保胎失败组),检测3组孕妇血清孕酮,并使用彩色多普勒超声检测孕妇子宫螺旋动脉和子宫动脉PI、RI和S/D,比较不同组孕妇血清孕酮和子宫螺旋动脉血流指标。结果:各组血清孕酮值存在差异(F=10.593,P=0.000<0.05),子宫动脉PI、RI和S/D无差异(F=1.028、1.359和0.948;P=0.168、0.105和0.199>0.05),子宫螺旋动脉PI、RI和S/D有差异(F=11.514、9.329和2.779;P=0.000、0.000和0.023<0.05);血清孕酮值、子宫螺旋动脉PI和RI联合预测早期先兆流产妊娠结局的灵敏性、特异性和准确性分别为85.5%、97.6%和95.8%。结论:早期先兆流产患者血清孕酮值和子宫螺旋动脉血流指标较正常妊娠女性存在差异,血清孕酮值、子宫螺旋动脉PI和子宫螺旋动脉RI可作为早期先兆流产诊断和预后评价指标,3项指标联合检测可提高早期先兆流产妊娠结局的预测特异性和准确性,妇科临床应予以重视。Objective： To observe the predictive effect of serum progesterone detection combined with uterine spiral ar terial flow ultrasound on pregnancy outcome in patients with threatened abortion. Methods： 400 women with early pregnancy from Chongqing Banan district people＇s hospital were selected as research subjects between August 2015 and August 2017, which Included 200 women with normal pregnancy （normal pregnant group）, 138 early threatened abortion women with tocolysis successful （tocolysis success group）, 62 early threatened abortion women with tocolysis failure （tocolysis failure group）. Serum progesterone of all pregnant women in the three groups was detected. PI, R1 and S/D of uterine spiral and uterine arteries of women in the three groups were detected by color doppler ultrasonography. Serum progesterone and uterine spiral artery blood flow index were compared among the three groups. Results.. There was difference in serum progesterone level of women among the three groups （F=10.593, P=0.000〈0.05）, and there was no difference in P1, RI and S/D of uterine artery among the three groups （F= 1.028, 1.359 and 0.948;P= 0.168, 0.105 and 0.199〉0.05）, but there was difference in PI, RI and S/D of uterine spiral artery among the three groups （F=11.514, 9.329 and 2.779;P：0.000, 0.000 and 0.023〈0.05）. The sensitivity, specificity and accuracy of serum progesterone combined with PI and RI of uterine spiral artery to predict the pregnancy outcome of early threat ened abortion were 85.48 % , 97.63% and 95.75% , respectively. Conclusion： The serum progesterone value and uterine spiral arterial blood flow index in pregnant women with early threatened abortion are different from those of normal pregnant women. The value of serum progesterone, PI and RI of uterus spiral artery can be used as a diagnostic and prognostic indicator for early threatened abortion. The using of combination of these three indicators can improve the prediction specificity and accuracy of pregnant outcome of wome

关 键 词：孕酮 子宫螺旋动脉血流 早期先兆流产 妊娠结局 预测 

分 类 号：R714.21[医药卫生—妇产科学]