黄芩苷镁盐与黄芩素肠吸收动力学比较研究  

Comparison Study of Baicalin Magnesium Salt and Baicalein on Intestinal Absorption Kinetics

作　　者：许海舰[1] 刘一鑫 宋鸿儒[2] 刘翠哲[1] 

机构地区：[1]承德医学院,河北省中药研究与开发重点研究实验室,河北承德067000 [2]河北北方学院,河北张家口075000

出　　处：《亚太传统医药》2018年第3期17-19,共3页Asia-Pacific Traditional Medicine

基　　金：河北省自然科学基金项目(H2014406036);河北省教育厅重点研究项目(ZH2012050)

摘　　要：目的:探讨黄芩苷镁盐和黄芩素的肠吸收动力学异同。方法:采用高效液相色谱法(HPLC)测定样品中黄芩苷镁盐和黄芩素的含量,计算黄芩苷镁盐和黄芩素的吸收速率常数(Ka),单位面积肠吸收量(Abs)和每小时吸收率(P)等肠吸收动力学参数,比较黄芩苷镁盐和黄芩素的肠吸收差异。结果:黄芩素的Ka是黄芩苷镁盐的2.33倍,Abs是黄芩苷镁盐的4.58倍,P是黄芩苷镁盐的3.86倍,差异有统计学意义(P<0.05)。结论:与黄芩苷镁盐比较,黄芩素在大鼠肠道的吸收更好、更快。Objective:This study was to discuss the similarities and differences of baicalin magnesium salt and baicalein respecting the intestinal absorption kinetics.Methods:HPLC method had been established to assay the contents of baicalin magnesium salt and baicalein,and the intestinal absorption kinetics parameters containing the absorption rate constant(Ka),the intestinal absorption by per unit area within one hour(Abs)and the absorption rate by hour(P)were figured out to investigate the differences of their absorption.Results:The Ka of baicalein was 2.33 times than that of baicalin magnesium salt,the Abs was 4.58 times and the P was3.86 times.There were significant differences of these data(P<0.05).Conclusion:The intestinal absorption of baicalein was better and quicker than baicalin magnesium salt in rats whole intestine tract.

关 键 词：黄芩苷镁盐 黄芩素 高效液相色谱法 肠吸收动力学 

分 类 号：R28[医药卫生—中药学]