间歇式静电纺丝制备纳米纤维药物控释系统  

Nanofiber Prepared by Intermittent Electrospun as Controlled Drug Delivery

作　　者：母朝静[1,2] 吴庆生 

机构地区：[1]同济大学化学科学与工程学院,上海200092 [2]上海市化学品分析风险评估与控制重点实验室,上海200092

出　　处：《同济大学学报（自然科学版）》2018年第3期406-415,共10页Journal of Tongji University:Natural Science

基　　金：国家自然科学基金(21471114;51771138);国家"九七三"重点基础研究发展计划(2011CB932404)

摘　　要：利用间歇式静电纺丝技术,分别以聚乳酸(PLLA)、聚己内酯(PCL)、聚乙烯吡咯烷酮(PVP)、聚丙烯腈(PAN)、聚乙二醇(PEG)等高分子材料单独或以不同配比制备纳米纤维.针对纺丝过程中容易出现的黏连现象,通过间歇式静电纺丝技术的控制,有效避免了黏连.对所得纳米纤维产品的形貌、结构、性质进行表征,初步考察所制备的纳米纤维在不同溶液中的降解行为,以选择合适的体系作为可控降解的载体担载不同的药物,构建载药复合纳米纤维.Biodegradable polymers, such as polylactic acid （PLLA）, poly-ε-caprolactone （ PCL）, polyvinylpyrrolidone （PVP）, polyacrylonitrile （PAN）, polyethylene glycol （PEG）, etc. with different ratios were intermittent electrospun to obtain nanofibers. The morphologies, structures, and properties of those nanofibers were characterized by SEM, XRD, FT-IR, etc. The degradation behavior of nanofibers was investigated in different solution. By analyzing the use of different degradation behaviors, the carrier for different types of DDS was preliminarily discussed for choosing suitable controllable-degradation carrier for different drugs to construct drug composite nanofibers.

关 键 词：间歇式静电纺丝 纳米纤维 药物传递系统 可控降解 

分 类 号：O636.9[理学—高分子化学] TQ342.9[理学—化学]