紫堇中的苯丙酰胺类成分  

Phenylpropanoid amides from whole plants of Corydalis edulis

作　　者：彭治添 晁凌会 霍会霞 陈孝男 姚会娜 张媛[1] 赵云芳[1] 屠鹏飞[1] 郑姣[1] 李军[1] 

机构地区：[1]北京中医药大学中药学院中药现代研究中心

出　　处：《中国中药杂志》2018年第1期109-113,共5页China Journal of Chinese Materia Medica

基　　金：教育部新世纪优秀人才支持计划项目(NCET-13-0693);北京中医药大学自主课题(2017-JYB-XS-069)

摘　　要：利用硅胶、Sephadex LH-20、ODS和半制备HPLC等色谱技术对紫堇Corydalis edulis的化学成分进行研究。通过理化性质和MS,NMR,UV,IR等谱学数据共鉴定了10个苯丙酰胺类化合物,分别为N-反式-芥子酰-3-甲氧基酪胺-4＇-O-β-葡萄糖苷（1）,N-反式-芥子酰-3-甲氧基酪胺（2）,N-反式-芥子酰酪胺（3）,N-反式-p-香豆酰酪胺（4）,N-反式-芥子酰-7-羟基酪胺（5）,N-顺式-阿魏酰酪胺（6）,N-顺式-p-香豆酰酪胺（7）,N-反式-阿魏酰酪胺（8）,N-反式-阿魏酰-3-甲氧基酪胺（9）,N-反式-阿魏酰-7-羟基酪胺（10）。其中化合物1为新化合物,化合物2-7为首次从罂粟科植物中分离得到,化合物8-10为首次从该植物中分离得到。Ten phenylpropanoid amides were isolated from the whole plants of Corydalis edulis Maxim.by various of column chromatographies including silica gel,Sephadex LH-20,and ODS.Their structures were identified on the basis of physicochemical properties,MS,NMR,and IR spectroscopic data.These compounds were identified as N-trans-sinapoyl-3-methoxytyramine-4＇-O-β-glucoside（1）,N-trans-sinapoyl-3-methoxytyramine（2）,N-trans-sinapoyltyramine（3）,N-trans-p-coumaroyltyramine（4）,N-trans-sinapoyl-7-hydroxytyramine（5）,N-cis-feruloyltyramine（6）,N-cis-p-coumaroyltyramine（7）,N-trans-feruloyltyramine（8）,N-trans-feruloyl-3-methoxytyramine（9）,and N-trans-feruloyl-7-hydroxytyramine（10）.Compound 1 is a new compound.Compounds 2-7 are obtained from the plants of Papaveraceae for the first time,while compounds 8-10 are firstly isolated from C.edulis.

关 键 词：紫堇 苯丙酰胺 生物碱 化学成分 

分 类 号：R284.1[医药卫生—中药学]