灯盏生脉胶囊治疗急性脑梗死的临床研究  

Clinical trial of Dengzhan Shengmai capsule in the treatment of patients with acute cerebral infarction

作　　者：黄攀 何晓英 

机构地区：[1]西南医科大学附属医院神经内科,四川泸州646000

出　　处：《中国临床药理学杂志》2018年第5期504-506,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家"十一五"科技支撑计划重大专项基金资助项目(2006BAI04A02);四川省应用基础研究计划基金资助项目(2014JC01662)

摘　　要：目的观察灯盏生脉胶囊对急性脑梗死患者颈动脉粥样硬化斑块及血流动力学的影响。方法将我院收治的196例急性脑梗死患者分为试验组和对照组,每组98例。对照组给予常规治疗,试验组在对照组的基础上给予灯盏生脉胶囊,每次0.36 g,每日3次。2组均治疗14 d。比较2组患者的临床疗效、颈动脉收缩期最大血流速度(PSV)、舒张末期血流速度(EDV)、阻力指数(RI)、搏动指数(PI)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及颈动脉内膜中层厚度(IMT)、颈动脉斑块面积、颈动脉狭窄率及药物不良反应发生情况。结果治疗后,试验组总有效率为89.80%(88例/98例),对照组为78.57%(77例/98例),差异有统计学意义(P<0.05)。治疗后,试验组颈动脉斑块面积、颈动脉内膜中层厚度和颈动脉狭窄率分别为(13.12±3.23)mm2,(0.98±0.08)mm,(34.35±8.52)%;对照组分别为(14.84±3.31)mm2,(1.13±0.09)mm,(39.74±9.64)%,差异均有统计学意义(均P<0.05)。治疗后,试验组PSV,EDV,RI和PI分别为(78.78±15.09)cm·s^(-1),(23.47±3.78)cm·s^(-1),0.75±0.04,1.30±0.24;对照组分别为(70.35±14.75)cm·s^(-1),(22.25±3.40)cm·s^(-1),0.81±0.05,1.37±0.25,差异均有统计学意义(均P<0.05)。治疗后,试验组TG,TC,HDL-C,LDL-C分别为(1.97±0.19),(5.48±0.49),(1.58±0.12),(2.04±0.18)mmol·L~(^(-1));对照组分别为(2.05±0.20),(5.69±0.51),(1.27±0.10),(2.18±0.21)mmol·L~(^(-1)),差异均有统计学意义(均P<0.05)。治疗过程中,2组患者均未发生药物不良反应。结论灯盏生脉胶囊可改善脑梗死患者颈动脉粥样硬化性斑块、血脂和血流动力学水平,可改善脑梗死预后,且安全有效。Objective To observe the effect of Dengzhan Shengmai cap- sule on carotid atherosclerotic plaque and hemodynamics in patients with cerebral infarction. Methods A total of 196 patients with acute recur- rent cerebral infarction were divided into treatment group and control group. Control group was given routine treatment. Treatment group was given Dengzhan Shengmai capsule 0. 36 g, 3 times a day. All the patients were treated for 14 d. The clinical effect, peak systolic velocity （ PSV）, end diustolic velocities （ EDV）, resistance index （ RI）, pulsa- tility index （PI）, triglyceride （TG）, total cholesterol （TC）, high densi- ty lipoprotein （ HDL - C ）, low density lipoprotein （ LDL - C ）, intima media thickness （IMT）, the plate area and adverse drug reaction were compared in two groups. Results After treatment, the total effectiverates of treatment group and control group were 89.80% （88 cases/98 cases）, 78.57% （77 cases/98 cases）, with significant difference （P 〈 0. 05 ）. After treatment, the plate area, IMT and carotid stenosis rate in treatment group were（ 13. 12± 3.23 ） mm2, （ 0. 98 ± 0. 08 ） mm, （ 34. 35 ± 8.52 ） %, had significant difference with those in control group, which were （ 14. 84 ± 3.31 ） mm2, （ 1.13 ± 0. 09 ） mm, （ 39.74 ± 9. 64） % （ P 〈 0. 05 ）. The PSV, EDV, RI and PI in treatment group were （ 78. 78 ±15. 09 ） cm·s-1, （23.47±3.78） cm·s-1, 0.75±0.04, 1.30±0.24, had significant difference with those in control group, which were （70. 35 ± 14. 75 ） cm · s-1, （ 22. 25 ± 3.40） cm· s -1 , 0.81 ± 0.05, 1.37 ± 0.25 （ P 〈 0.05 ）. The TG, TC, I-IDL - C, LDL - C in treatment group were （ 1.97 ± 0. 19 ）, （5.48 ±0. 49）, （1.58±0. 12）, （2.04±0. 18）mmol · L-1, had significant difference with those in control group, which were （2.05 ±0.20）,（5.69 ±0.51）,（1.27±0. 10）,（2. 18 ±0.21）mmol· L-1（P 〈0.05）. There was no obvious adverse drug reaction during the

关 键 词：灯盏生脉胶囊 动脉粥样硬化 血脂 

分 类 号：R973.2[医药卫生—药品]