血栓调节蛋白对于感染性休克患者预后的评估价值  

Clinical significance of thrombomodulin in treatment for patients with septic shock

作　　者：秦燕明[1] 李政[1] 王鹏[1] 崔恒熙[1] 

机构地区：[1]江苏大学附属人民医院急诊医学中心,镇江212000

出　　处：《中国急救复苏与灾害医学杂志》2018年第2期139-141,共3页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：江苏省镇江市科技计划（社会发展科技支撑项目）（SH2013050）

摘　　要：目的探讨血栓调节蛋白对于感染性休克患者预后评估的临床价值。方法感染性休克患者60例，根据患者预后分为存活组33例、死亡组27例，患者人ICU后第1、3、5、7天检测血栓调节蛋白、血乳酸值以及计算急性生理学与慢性健康状况评分Ⅱ（aeatephysiologyandchronichealthevaluation，APACHEⅡ评分），对不同时间点的检测值变化进行统计学分析，并分析指标间的相关性。结果死亡组的血乳酸、血栓调节蛋白值和APACHEⅡ评分均显著高于存活组，差异有统计学意义（P〈0．05）；血栓调节蛋白值与APACHEⅡ评分均有较好的正相关性（r=0．670，P〈0．01），血乳酸与APACHEⅡ评分具有正相关性（r=O．510，P〈0．01）；血栓调节蛋白与血乳酸之间无显著相关性（r=0．210，P〉0．05）。结论血栓调节蛋白与APACHEⅡ评分具有较好的相关性，动态监测血栓调节蛋白值对判断感染性休克患者的危重程度和预后具有指导意义。Objective To study the Clinical significance of thrombomodulin in treatment for patients with septic shock. Methods A retrospective study of 60 patients with septic shock was enrolled in this study.These patients were divided into survival group（33cases） and death group（27cases） according to the prognosis. The levels of plasma thrombomodulin and blood lactate were detected dynamically at the 1, 3, 5, 7 day after admission.All the patients were subjected to the calculation of APACHE（acute physiology and chronic health evaluation） ]I scores at same time. Results The levels of thrombomodulin , blood lactate and APACHE Ⅱ scores of the death group was significantly higher than the survival group （P〈0.05）, The APACHE Ⅱ scores was positive correlated with thromhomodulin （ r = 0.670, P〈 0.01） and blood lactate level （ 1=0.510, P〈 0.01）, on the orther hand , no significant correlation was seen between thrombomodulin and blood lactate（ r =0.210, P〉0.05）. Conclusion Dynamic detection of the thrombomodulin can guide the treatment in patients with septic shock, because its positive correlated with APACHE Ⅱ scores.

关 键 词：血栓调节蛋白 血乳酸 APACHE Ⅱ评分 感染性休克 

分 类 号：R446.1[医药卫生—诊断学]