皖西地区发热伴血小板减少综合征现状调查  

Survey on antibody of severe fever with thrombocytopenia syndrome bunyavirus(SFTSV) in west of Anhui Province

作　　者：解少煜 吕勇[1] 孙婕[1] 徐鹏鹏[1] 常宏伟[1] 秦伟[1] 李开春[1] 胡颉颖 袁伟 俞亮 谢华 李光江 杨承武 张丽梅[1] 张凤[1] 丁凡[4] 王芹[4] 李德新[4] 王德斌[5] Xie Shaoyu, Lu Yong, Sun Jie, et al(Lu＇ an City Center for Disease Control and Prevention, Lu＇ an 23700)

机构地区：[1]六安市疾病预防控制中心,六安237000 [2]金寨县疾病预防控制中心,金寨233000 [3]霍山县疾病预防控制中心,霍山237200 [4]中国疾病预防控制中心,北京100000 [5]安徽医科大学卫生管理学院,合肥230032

出　　处：《安徽医科大学学报》2018年第3期386-389,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81661138001)

摘　　要：目的了解发热伴血小板减少综合征(SFTS)在皖西高发地区一般人群布尼亚病毒(SFTSV)Ig G抗体阳性率,分析其流行规律。方法从中国疾病预防控制信息系统中按照报告病例数进行排序,采取多阶段整群随机抽样的方法选取了2 126例作为调查对象,通过采集血液标本并分离血清,采用ELISA法检测SFTSV-Ig G抗体,分析发病与感染的相关性。结果 SFTSV-Ig G总抗体阳性率4.66%。不同行政村间阳性率差异有统计学意义(χ2=54.28,P<0.01),SFTSV血清阳性数和SFTS发病数之间存在线性回归关系(F=11.51,P<0.01),不同性别间阳性率差异无统计学意义,不同年龄组间阳性率差异无统计学意义,SFTSV-Ig G抗体阳性率随着年龄的增长呈现波浪式的上升,从事不同职业间阳性率差异有统计学意义(χ2=15.21,P=0.01)。结论一般人群对SFTSV普遍易感,皖西SFTS高发病地区SFTSV感染率较高。Objective To understand the infection status of severe fever with thrombocytopenia syndrome bunyavir- us （SFTSV） in high incidence area west of Anhui Province through detecting IgG, so as to analyze their epidemical rule. Methods China information system for disease control and prevention was used to rank order the counties ac- cording to the number of SFTS cases. Multi-stage cluster random sampling method was use to select 2 126 healthy people from these rank orders counties. SFTSV-IgG antibodies were determined by indirect ELISA. The correlation between the disease incidence and infection was analyzed by statistical methods. Results The seroprevalence of SFTSV-IgG was 4. 66%. The difference of seroprevalence between different administrative villages was statistically significant（ X2 = 54. 28 ,P 〈0.01 ）. There was linear regression relationship between the numbers of SFTSV infec- tion and the ones of SFTS cases （F = 11.51 ,P 〈0. 01 ）. The age and gender had no difference in seroprevalence but higher numbers of SFTSV infection were observed in older groups. The difference in seroprevalence between different occupation groups was also statistically significant （ X2 = 15. 21, P = 0. 01 ）. Conclusion General popu- lation are susceptible to SFTSV. SFTSV infection rate is higher in west Anhui Province than the other areas.

关 键 词：发热伴血小板减少综合征布尼亚病毒 流行病学 感染率 

分 类 号：R183.5[医药卫生—流行病学]