潮气呼吸肺功能与呼出气一氧化氮检测对2～5岁哮喘患儿临床价值研究  

Clinical value of the test of tidal breathing lung function and exhaled nitric oxide in asthmatic children aged 2 to 5

作　　者：张惠琴[1] 张静静[1] 陶小娟[1] 樊蕊[1] 孙新[1] 

机构地区：[1]第四军医大学西京医院儿科,陕西西安710032

出　　处：《中国实用儿科杂志》2018年第3期229-232,共4页Chinese Journal of Practical Pediatrics

摘　　要：目的探讨潮气呼吸肺功能检测及呼出气一氧化氮(Fe NO)检测在2~5岁儿童哮喘中的临床价值。方法选择2012年1月至2015年6月在第四军医大学西京医院儿科首次诊治的216例哮喘儿童为哮喘组,以同期128例正常儿童为对照组。分别测定哮喘患儿急性期及缓解期潮气呼吸肺功能与Fe NO水平,并与对照组进行比较。比较支气管舒张试验前后肺功能变化。分析Fe NO水平与肺功能参数之间的相关性。结果哮喘急性期的达峰时间比(TPEF/TE)、达峰容积比(VPEF/VE)均明显低于哮喘缓解期和对照组(均P<0.05)。哮喘缓解期的TPEF/TE、VPEF/VE有所恢复,但仍低于对照组(P<0.05)。哮喘组急性期支气管舒张试验后TPEF/TE、VPEF/VE较试验前明显改善(P<0.05)。以TPEF/TE、VPEF/VE任意一个改善率≥15%为舒张试验阳性,阳性率69.90%。哮喘组急性期及缓解期的Fe NO[(35.50±14.13)×10^(-9),(28.16±5.52)×10^(-9)]均高于对照组(12.77±7.00)×10^(-9)(P<0.05),且急性期Fe NO水平高于缓解期(P<0.05)。哮喘组急性期及缓解期TPEF/TE、VPEF/VE均与Fe NO无相关性。结论 Fe NO、肺功能检测及支气管舒张试验互为补充,共同应用可有助于低龄儿童哮喘管理。Objective To study the clinical value of the test of tidal breathing lung function and exhaled nitric oxide in asthmatic children aged 2 to 5. Methods 216 children with asthma treated from January 2012 to June 2015 in the Pediatric Department of Xijing Hospital of Fourth Military Medical University were listed in asthma group, and 128 normal children in the same period were selected as control group. Tidal breathing lung function and exhaled nitric oxide at the acute and remission stages of asthma were tested respectively, and compared with control group. Tidal breathing lung function were compared before and after bronchial dilation test. Correlation between exhaled nitric oxide level and tidal breath lung function parameters was analyzed. Results The ratio of time to peak tidal expiratory flow to total expiratory time （TPEF/TE） and ratio of volume to peak expiratory flow to total expiratory volume （VPEF/VE） in acute stage of asthma group were significantly lower than those of the asthma group in the remission stage and the control group （P 〈 0.05）. TPEFfFE and VPEF/VE had significantly improved in asthma group in remission stage, but were still significantly lower than those of the control group （P 〈 0.05 ）. TPEF/ TE and VPEF/VE had significantly improved after bronchial dilation test in the acute stage of asthma group （P 〈 0.05 ）. Taking an improvement rate of≥15% either for TPEF/TE or for VPEF/VE as an indicator of positive bronchial dilation test, thus the positive rate was 69.90%. The levels of FeNO in acute and remission stages of asthma group [ （35.50± 14.13 ）×10^-9, （28.16± 5.52 ）×10^-9] were significantly higher than those of the control group [ （12.77±7.00） ×10^-9（P 〈 0.05 ） ], and the levels of FeNO in acute stage of asthma group were significantly higher than those of asthma group in remission stage （P 〈 0.05）. FeNO levels were not correlated with TPTEF/TE and VPEF/VE in acute or in remission stages of asthma group. Conclusion Tidal breathing

关 键 词：潮气呼吸 肺功能 呼出气一氧化氮 儿童 哮喘 

分 类 号：R72[医药卫生—儿科]