肠道微生态失衡为骨质疏松症发病的易感因素  

The imbalance of gut microecology may be a susceptible factor of osteoporosis

作　　者：董万涛[1,2] 黄凯 宋敏 侯红燕[1] 宋志靖 周灵通[1] 刘小钰[1] 蒋林博[1] 

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃中医药大学附属医院,甘肃兰州730020

出　　处：《中国骨质疏松杂志》2018年第3期394-398,共5页Chinese Journal of Osteoporosis

基　　金：甘肃省自然科学基金计划(17JR5RA056);甘肃省自然科学基金计划(1506RJZA048);甘肃省中医药防治慢性疾病重点实验室开放基金项目(GSMBKY2015-07);甘肃省中医药管理局科研课题(GZK-2016-17);甘肃省中药现代制药工程研究院项目(YWW-2015049)

摘　　要：本文通过综述人体肠道菌群和骨代谢的相关性研究,从衰老与胃肠道功能不足是老年性骨质疏松的危险因素、炎症性肠病是并发骨质疏松的危险因素、糖皮质激素是IBD诱发骨质疏松的重要因素、肠道菌群失调是绝经后骨质疏松发生的关键因素等方面探讨了肠道微生态失衡与骨质疏松发生发展的相关性,并从肠道微生态出发对老年性骨质疏松的危险因素和绝经后骨质疏松发生的关键因素做了深入探讨,通过综述国内外实验和临床研究,认为肠道微生态失衡是骨质疏松症发病的易感因素。In this paper,the relationship between the imbalance of gut flora and osteoporosis is explored by reviewing the correlation between gut flora and bone metabolism in the human body,the aging and gastrointestinal dysfunction in senile osteoporosis,the inflammatory bowel disease,the glucocorticoid in IBD-induced osteoporosis,and the imbalance of gut flora in postmenopausal osteoporosis. The risk factors of senile osteoporosis and the key factors of postmenopausal osteoporosis are deeply based on intestinal microecology. According to the review of domestic and international experimental and clinical research,we believe that the intestinal microecological imbalance is the predisposing factor of osteoporosis.

关 键 词：骨质疏松症 肠道菌群 肠道微生态 易感因素 

分 类 号：R681[医药卫生—骨科学]