利巴韦林注射液联合脾氨肽治疗手足口病的疗效分析  

Efficacy analysis of ribavirin injection combined with spleen aminopeptide in the treatment of hand-foot-and-mouth disease

作　　者：郭瑜 GUO Yu(Guangdong Dongguan Qiaotou Hospital, Dongguan 523523, Chin)

机构地区：[1]广东省东莞市桥头医院,523523

出　　处：《中国实用医药》2018年第8期94-95,共2页China Practical Medicine

摘　　要：目的探讨利巴韦林注射液联合脾氨肽治疗手足口病的临床疗效。方法 96例手足口病患儿,随机分为对照组和治疗组,各48例。两组患儿均给予退热、有细菌感染的给予抗感染等对症治疗,在此基础上,对照组给予利巴韦林注射液治疗,治疗组在对照组基础上口服脾氨肽口服冻干粉治疗。比较两组的治疗效果。结果治疗组治疗总有效率97.92%高于对照组81.25%,差异具有统计学意义(P<0.05)。治疗组口腔疱疹消退时间、手足皮疹消退时间、退热时间、平均住院时间均短于对照组,差异均具有统计学意义(P<0.05)。结论利巴韦林注射液联合脾氨肽治疗手足口病有良好的协同作用,可提高治疗效果,缩短住院时间,值得基层临床推广。Objective To discuss the clinical efficacy of ribavirin injection combined with spleen aminopeptide in the treatment of hand-foot-and-mouth disease. Methods A total of 96 children with hand-footand-mouth disease were randomly divided into control group and treatment group, with 48 cases in each group. Both groups received symptomatic treatment of antipyretic and anti-infection therapy, and on its basis, the control group was treated with ribavirin injection. The treatment group was treated with oral spleen aminopeptide freezedried powder. The treatment effect in two groups was compared. Results The treatment group had higher total treatment effective rate as 97.92% than 81.25% in the control group, and the difference was statistically significant（P〈0.05）. The treatment group had shorter oral herpes subsided time, hand-foot rash subsided time, antipyretic time and hospitalization time than the control group, and their difference was statistically significant（P〈0.05）. Conclusion Combination of ribavirin and spleen aminopeptide shows a good synergistic effect in treating handfoot-and-mouth disease, and can improve treatment effect and shorten hospitalization time. It is worthy of clinical promotion at the basic level.

关 键 词：利巴韦林 脾氨肽 手足口病 

分 类 号：R725.1[医药卫生—儿科]