P-糖蛋白分子结构及转运机制  

Molecular structure and mechanism of P-glycoprotein functions

作　　者：杨晓波[1] 刘克辛[1] YANG Xiaobo, LIU Kexin(College of Pharmacy, Dalian Medical University, Dalian 116044, Chin)

机构地区：[1]大连医科大学药学院,辽宁大连116044

出　　处：《药物评价研究》2018年第1期1-4,共4页Drug Evaluation Research

基　　金：国家自然科学基金项目(81473280;81502992)

摘　　要：P-糖蛋白(P-gp)是一种跨膜转运蛋白,属于三磷酸腺苷结合盒式结构转运蛋白超家族成员,其主要分布于肝脏、肾脏、胃肠道和血脑屏障等组织。一方面,P-gp在细胞营养的摄取、代谢物的排泄、能量的产生和细胞信号的传导等正常细胞生理学功能方面起到了至关重要的作用;另一方面,P-gp的过度表达也是造成肿瘤细胞多药耐药(MDR)的主要机制。介绍P-糖蛋白的分子结构和转运机制的相关研究进展,为其进一步研究提供参考。P-glycoprotein（P-gp） is one kind of membrane proteins which belongs to sub-family B of the ATP-binding cassette transporter superfamily. P-gp is mainly localized in the liver, kidney, gastrointestinal tract and blood brain barrier. On one hand, P-gp plays an important part in transporting ligands across cellular lipid membranes, which is critical for most aspects of cell physiology, including the uptake of nutrients and elimination of waste products, energy generation, and cell signaling. On the other hand, there is a greater likelihood of treatment failure if P-gp expression increases after therapy. One of the best-understood MDR involved mechanisms is the over-expression of P-gp. In the present review, we will provide the latest advances in the studies of the molecular structure basis and the mechanism of P-glycoprotein functions.

关 键 词：膜转运蛋白 P-糖蛋白 多药耐药 分子结构 

分 类 号：R962.2[医药卫生—药理学]