瑞舒伐他汀钙与阿托伐他汀钙对动脉粥样硬化急性脑梗死合并高血脂的疗效比较  

Comparison of rosuvastatin calcium and atorvastatin calcium in treatment of atherosclerosis acute cerebral infarction combined with hyperlipidemia

作　　者：韩石蕊[1] 赵永旗[1] 程洪兵[1] 郭社民 HAN Shirui1, ZHAO Yongqi1, CHENG Hongbing1, GUO Shemin2(1. Pharmacy Department, People＇s Hospital of Puyang, Puyang 457000, China 2. Inspection test center, Puyang Food and Drug Inspection Testing Center, Puyang 457000, Chin)

机构地区：[1]濮阳市人民医院,河南濮阳457000 [2]濮阳市食品药品检验检测中心,河南濮阳457000

出　　处：《药物评价研究》2018年第1期122-125,共4页Drug Evaluation Research

摘　　要：目的对比瑞舒伐他汀钙与阿托伐他汀钙对动脉粥样硬化急性脑梗死合并高血脂的临床疗效。方法选择2015年4月—2016年10月濮阳市人民医院收治的动脉粥样硬化急性脑梗死合并高血脂患者102例,根据随机数字表法,平均分为瑞舒伐他汀钙组和阿托伐他汀钙组。比较两组治疗前及治疗后的肝功能、血糖及血脂等指标,以及治疗后的不良反应及神经功能缺损评分(NIHSS)。结果与阿托伐他汀钙组相比,瑞舒伐他汀钙组的有效率明显较高,差异有统计学意义(P<0.05)。两组治疗后肝功能、血糖、血脂、CK指标及NIHSS评分均优于治疗前,同组治疗前后比较差异有统计学意义(P<0.05)。治疗后两组肝功能、血糖、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、肌酸激酶(CK)指标及不良反应对比无统计学意义;而治疗后瑞舒伐他汀钙组的低密度脂蛋白胆固醇(LDL-C)及NIHSS评分均明显优于阿托伐他汀钙组,差异有统计学意义(P<0.05)。结论瑞舒伐他汀钙与阿托伐他汀钙治疗动脉粥样硬化急性脑梗死合并高血脂症疗效相当,而瑞舒伐他汀钙在改善神经功能及LDL-C指标方面优于阿托伐他汀钙。Objective To compare the clinical efficacy of rosuvastatin calcium and atorvastatin calcium in treatment of atherosclerosis acute cerebral infarction combined with hyperlipidemia. Methods 102 cases with rosuvastatin calcium and atorvastatin calcium in People＇s Hospital of Puyang from Apr. 2015 to Oct. 2016 in our hospital were chosen, who were divided into the rosuvastatin calcium group and atorvastatin calcium group. The liver function indexes, blood glucose and blood lipid of two groups before and after treatment were compared, the adverse reactions and NIHSS score of two groups after treatment were compared. Results Compared with atorvastatin calcium, the rosuvastatin calcium total efficacy was higher（P〈0.05）. The liver function indexes, blood glucose, blood lipid, CK and NIHSS score of two groups after treatment were better than before treatment（P〈0.05）. The liver function indexes, blood glucose, TG, TC, HDL-C, CK and NIHSS scores of two groups had no significant difference,. The LDL-C and adverse reactions of two groups after treatment had no significant difference（P〈0.05）. Conclusion Rosuvastatin calcium and atorvastatin calcium in treatment of atherosclerosis acute cerebral infarction combined with hyperlipidemia were therapeutic equivalence, while the rosuvastatin calcium could improve the neurological function and LDL-C better than atorvastatin calcium.

关 键 词：动脉粥样硬化 急性脑梗死 高血脂 瑞舒伐他汀钙 阿托伐他汀钙 

分 类 号：R972.6[医药卫生—药品]