丙氨酰谷氨酰胺对危重有机磷中毒患者免疫功能及神经功能的影响  

Effects of alanyl-glutamine on immune function and neurological function in patients with severe organophosphorus poisoning

作　　者：白海峰[1] 李卫民[1] 田亚军 李杰[1] 焦军林 刘宏伟[1] BAI Haifeng, LI Weimin, TIAN Yajun, LI Jie, JIAO Junlin, LIU Hongwei(Emergency Department, The First Hospital ofYulin, Yulin 719000, Chin)

机构地区：[1]榆林市第一医院急诊科,陕西榆林719000

出　　处：《药物评价研究》2018年第2期287-290,共4页Drug Evaluation Research

摘　　要：目的探讨丙氨酰谷氨酰胺对危重有机磷中毒患者免疫功能及神经功能的影响。方法将榆林市第一医院自2012年1月—2016年12月收治的86例危重有机磷中毒患者作为研究对象,随机分为对照组和研究组,每组43例,对照组患者采用复能剂氯解磷定、解毒剂阿托品、血液灌流以及其他对症治疗,研究组患者在对照组治疗的基础上静脉注射丙氨酰谷氨酰胺注射液,连续治疗3 d后观察两组患者的临床效果、神经功能、免疫功能等指标。结果研究组患者中毒症状消失时间、全血胆碱酯酶恢复时间、住院时间、F波潜伏期均显著少于对照组,差异有统计学意义(P<0.05)。治疗后研究组患者腓总神经的运动神经传导速度(MCV)、感觉神经传导速度(SCV)水平均显著高于对照组,差异有统计学意义(P<0.05)。两组IgG、IgA、IgM、TLC等指标相比于治疗前显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且研究组显著高于对照组,差异有统计学意义(P<0.05)。结论丙氨酰谷氨酰胺可以使重症有机磷中毒患者的临床症状得到缓解,改善神经功能及免疫功能,效果显著,可推广使用。Objective To investigate the effect of alanylglutamine on immune function and neurological function in critically ill organophosphate poisoning patients.Methods 86 cases of critically ill organ ophosphorus poisoning patients admitted in our hospital from January 2012 to December 2016 were randomly divided into study group and control group.The control group was given Antiperspirant atropine,complex agent chlorpheniramide,hemoperfusion and other symptomatic treatment,the study group of patients in the control group based on the intravenous injection of alanyl glutamine injection,continuous treatment three days after two groups of patients observed clinical effects and immune function and neurological function and other indicators.Results The time of disappearance of poisoning symptoms,the recovery time of cholinesterase in whole blood and the time of hospitalization were significantly lower than those of the control group（P〈0.05）.After treatment,the levels of MCV and SCV were significantly higher in the study group than those in the control group（P〈0.05）.The scores of IgG,IgA,IgM and TLC in the study group were significantly higher than those in the control group before,and the difference was statistically significant（P〈0.05）.Conclusion Alanylglutamine can effectively relieve the clinical symptoms of patients with severe organophosphate poisoning,improve neurological function and immune function,the effect is remarkable,can be used.

关 键 词：危重有机磷中毒 丙氨酰谷氨酰胺 神经系统功能 免疫功能 

分 类 号：R969.4[医药卫生—药理学]