金匮肾气片联合坦索罗辛治疗膀胱过度活动症的疗效观察  

Clinical observation of Jingui Shenqi Tablets combined with tamsulosin in treatment of overactive bladder

作　　者：宗德斌[1] 赵积晔[1] 田兵[1] 荆孝东[1] 李猛[1] 李勇[1] 胡明宇[1] 

机构地区：[1]大连大学附属新华医院泌尿外科,辽宁大连116021

出　　处：《现代药物与临床》2018年第2期351-354,共4页Drugs & Clinic

摘　　要：目的观察金匮肾气片联合盐酸坦索罗辛治疗膀胱过度活动症的临床疗效。方法选取2016年7月—2017年6月在大连大学附属新华医院就诊的膀胱过度活动症患者106例,随机分为对照组和治疗组,每组各53例。对照组饭后口服盐酸坦索罗辛缓释胶囊,0.2 mg/次,1次/d;治疗组在对照组基础上口服金匮肾气片,4片/次,2次/d。两组患者均治疗4周。观察两组患者临床疗效,比较治疗前后两组患者尿失禁生活质量评估量表(I-QOL)、膀胱过度活动症评分(OABSS)和排尿相关指标改善情况。结果治疗后,对照组临床总有效率为75.47%,显著低于治疗组的92.45%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组I-QOL均显著升高,OABSS显著降低,同组比较差异具有统计学意义(P<0.05);且治疗组患者I-QOL和OABSS水平明显优于对照组患者,两组比较差异具有统计学意义(P<0.05)。治疗后,两组24 h排尿次数、24 h夜尿次数和24 h急迫性尿失禁次数显著减少,最大尿流率(Q_(max))、平均尿流率(Q_(ave))和平均尿量(V_V)水平显著升高,同组比较差异具有统计学意义(P<0.05);且治疗组患者上述排尿指标改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论金匮肾气片联合盐酸坦索罗辛治疗膀胱过度活动症临床疗效确切,症状改善明显,具有一定的临床推广应用价值。Objective To observe the clinical effect of Jingui Shenqi Tablets combined with tamsulosin in treatment of overactive bladder. Methods Patients（106 cases） with overactive bladder in Dalian University Affiliated Xinhua Hospital from July 2016 to June 2017 were randomly divided into control and treatment groups, and each had 53 cases. Patients in the control group were po administered with Tamsulosin Hydrochloride Sustained Release Capsules after meals, 0.2 mg/time, once daily. Patients in the treatment group were po administered with Jingui Shenqi Tablets on the basis of the control group, 4 tables/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the improvement of the OABSS, I-QOL and urination related indexes in two groups before and after treatment was compared. Results After treatment, the clinical efficacy in the control group was 75.47%, which was significantly lower than 92.45% in the treatment group, and there were differences between two groups（P〈0.05）. After treatment, I-QOL in two groups was significantly increased, the OABSS was significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And I-QOL and OABSS in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, but 24 h urination times、24 h nocturia frequency and 24 h frequency of urgent incontinence in two groups were significantly decreased, but Q（max）, Q（aveand） VV levels were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. And these urination related indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Jingui Shenqi Tablets combined with tamsulosin has significant clinical curative effect in treatment of overactive bladder with obvious i

关 键 词：金匮肾气片 盐酸坦索罗辛缓释胶囊 膀胱过度活动症 临床疗效 尿失禁生活质量评估量表 膀胱过度活动症评分 平均尿流率 

分 类 号：R983[医药卫生—药品]