美罗培南联合头孢哌酮舒巴坦延长输注时间治疗泛耐药鲍曼不动杆菌性肺炎的临床研究  

Clinical Study on Meropenem Combined with Cefoperazone Sulbactam for Extending Infusion Time in the Treatment of Patients with Pneumonia Infected by Pan-Drug Resistent Acinetobacter Baumannii

作　　者：凌双[1] 林尚奋 杨春万[1] 慕容锐 周建勇[1] 麦玉婵 LING Shuang, LIN Shangfen, YANG Chunwan, MURONG Rui, ZHOU Jianyong, MAI Yuchan(Zhaoqing First People＇s Hospital, Zhaoqing 526020, Chin)

机构地区：[1]广东省肇庆市第一人民医院,广东肇庆526020

出　　处：《临床医学工程》2018年第3期327-328,共2页Clinical Medicine & Engineering

摘　　要：目的探讨美罗培南联合头孢哌酮舒巴坦延长输注时间治疗泛耐药鲍曼不动杆菌性肺炎的疗效和安全性。方法选取我院收治的70例泛耐药鲍曼不动杆菌性肺炎患者,随机分为两组,均采用美罗培南联合头孢哌酮舒巴坦治疗。实验组(32例)药物每次输注时间延长至3 h,对照组(38例)则在1 h内输注完毕。比较两组的临床疗效和不良反应。结果与对照组比较,实验组的临床治愈率较高,28 d死亡率较低,PCT水平、CPIS、SOFA均较优(P均<0.05)。两组的药物疗程、ICU住院时间、机械通气时间、细菌清除率、二重感染率、不良反应发生率比较均无统计学差异(P>0.05)。结论美罗培南联合头孢哌酮舒巴坦延长输注时间治疗泛耐药鲍曼不动杆菌性肺炎可提高患者的临床治愈率,促进器官功能恢复,改善其病情及预后。Objective To explore the curative effect and safety of meropenem combined with cefoperazone sulbactam for extending infusion time in the treatment of patients with pneumonia infected by pan-drug resistent acinetobacter baumannii. Methods 70 cases pf patients with pneumonia infected by pan-drug resistent acinetobacter baumannii admitted to our hospital were selected and ramdomly divided into two groups. Both groups were treated with meropenem combined with cefoperazone sulbactam. The experimental group （32 cases） extended the infusion time to 3 hours, while the control group （38 cases） completed the infusion within 1 hour. The clinical curative effect and adverse reactions were compared between the two groups. Results Compared with the control group, the clinical cure rate of the study group was higher, 28-day mortality rate was lower, and the PCT level, CPIS and SOFA were better （all P 〈0.05）. No statistical difference was found in the medicine course, ICU hospitalization time, mechanical ventilation time, bacterial clearance rate, secondary infection rate and incidence of adverse reactions between the two groups （P〉0.05）. Conclusions Meropenem combined with cefoperazone sulbactam for extending infusion time in the treatment of patients with pneumonia infected by pan-drug resistent acinetobacter baumannii can improve the clinical cure rate, promote the recovery of organ function, and improve the disease and prognosis.

关 键 词：美罗培南 头孢哌酮舒巴坦 延长输注时间 泛耐药鲍曼不动杆菌 肺炎 

分 类 号：R563.1[医药卫生—呼吸系统]