肿瘤细胞“炎化”与NF-κB信号通路的非编码RNA调控  

NcRNA regulation of the NF-κB pathway and intratumor-cell activation of inflammatory signaling

作　　者：刘湜桦 管洪宇[3] 黎孟枫[1,2] LIU Shi-Hua1＇2, GUAN Hong-Yu3, LI Meng-Feng1＇2.(1 Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China; 2 Key Laboratory of Tropical Disease Control （Sun Yat-Sen University）, Ministry of Education, Guangzhou 510080, China; 3 Department of Endocrinology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China)

机构地区：[1]中山大学中山医学院微生物系,广州510080 [2]热带病防治研究教育部重点实验室(中山大学),广州510080 [3]中山大学附属第一医院内分泌内科,广州市510080

出　　处：《生命科学》2018年第2期157-168,共12页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金重大项目(81490752);国家自然科学基金创新研究群体项目(81621004)

摘　　要：作为转录因子,NF-κB通过转录调节基因表达参与肿瘤的发生进展。诸多研究表明,几乎在所有肿瘤中都存在肿瘤细胞内NF-κB信号通路的持续激活。然而,本来在生理状态下受到严格调控的NF-κB信号通路在肿瘤细胞中如何持续地被激活,其细胞分子生物学机制尚不清楚。现就简要评述非编码RNA(miRNA和lncRNA)对肿瘤细胞内NF-κB炎性通路的调节及其可能的临床转化意义。Transcription factor NF-κB plays important roles in the development and progression of malignant tumor through regulating the expression of a wide variety of genes. Constitutive activation of NF-κB has been evidenced in many cancer types. While NF-κB signaling pathway is tightly regulated in physiological settings, quite frequently it is constitutively activated in cancer cells, leading the cancer cells to a status we designate as being ＂inflamized＂. The molecular biology mechanisms underlying the deregulated activation of NF-κB signaling, however, remain unclear. In this review, the regulatory role and possible clinical conversion of non-coding RNA（miRNA and lncRNA） in NF-κB signaling pathway in inflammatory tumor cells will be discussed.

关 键 词：NF-ΚB MIRNA lncRNA 炎化 肿瘤 

分 类 号：Q71[生物学—分子生物学]