Iron-Catalyzed Aerobic Oxidation of Aldehydes： Single Component Catalyst and Mechanistic Studies  

作　　者：Xingguo Jiang Yizhan Zhai Junyu Chen Yulin Han Zheng Yang Shengming Ma 

机构地区：[1]State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China [2]University of Chinese Academy of Sciences, Beijing 100049, China [3]Department of Chemistry, Fudan University, 220 Handan Lu, Shanghai 200433, China

出　　处：《Chinese Journal of Chemistry》2018年第1期15-19,共5页中国化学（英文版）

摘　　要：An aerobic oxidation of aldehydes towards carboxylic acids in MeCN using 1 atm of pure oxygen or oxygen in air as the oxidant and a catalytic amount of single component catalyst, Fe（NO3）3.9H20, has been developed. Carboxylic acids with different synthetically useful functional groups were obtained at room temperature. Two mechanistic pathways have been proposed based on isotopic labeling, NMR monitoring, and control experiments. The practicality of this reaction has been demonstrated by conducting several 50 mmol-scale reactions using pure oxygen or an air-flow of -30 mL/min.An aerobic oxidation of aldehydes towards carboxylic acids in MeCN using 1 atm of pure oxygen or oxygen in air as the oxidant and a catalytic amount of single component catalyst, Fe（NO3）3.9H20, has been developed. Carboxylic acids with different synthetically useful functional groups were obtained at room temperature. Two mechanistic pathways have been proposed based on isotopic labeling, NMR monitoring, and control experiments. The practicality of this reaction has been demonstrated by conducting several 50 mmol-scale reactions using pure oxygen or an air-flow of -30 mL/min.

关 键 词：iron catalysis aerobic oxidation ALDEHYDE carboxylic acid single component catalyst mechanistic studies 

分 类 号：O643.36[理学—物理化学] TQ432.2[理学—化学]