生物组织黏弹性激光散斑检测方法研究进展  

Viscoelasticity Measurement of Biological Tissues Using Laser Speckle Techniques:a Review

作　　者：陈肖[1,2] 陆锦玲 李鹏程[1,2] Chen Xiao1,2, Lu Jinling1,2, Li Pengcheng1,2(1Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan , Hubei 430074, China ; 2 MoE Key Laboratory for Biomedical Photonics, Collaborative Innovation Center for Biomedical Engineering, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, Hubei 430074, Chin)

机构地区：[1]华中科技大学-武汉光电国家研究中心、Britton Chance生物医学光子学研究中心,湖北武汉430074 [2]华中科技大学工程科学学院、生物医学光子学教育部重点实验室、生物医学工程协同创新中心,湖北武汉430074

出　　处：《中国激光》2018年第2期76-85,共10页Chinese Journal of Lasers

基　　金：国家重点研发计划(2017YFB1002503); 国家自然科学基金(31471083,61405065,61775071); 武汉光电国家实验室(筹)主任基金

摘　　要：生物组织的黏性和弹性在许多疾病发生和发展的过程中会发生改变,因此检测生物组织黏弹性对疾病诊疗具有重要意义。基于此,介绍了基于激光散斑技术的生物组织黏弹性测量方法。从弹性波调制下的激光散斑衬比变化,布朗运动下的光强自相关函数和低频交变应力作用下的散斑位移3个方面,分别介绍生物组织黏弹性激光散斑检测的理论基础和研究现状。Viscosity and elasticity of biological tissues will change during onset and progression of many diseases.Viscoelasticity measurement of biological tissues plays an important role in diagnosis of diseases.We particularly review some basic principles and recent advances of viscoelasticity measurement based on laser speckle techniques from three aspects：difference of laser speckle contrast under elastic waves,optical intensity autocorrelation curve under Brownian motion,and laser speckle shift under low frequency oscillation stress.

关 键 词：生物医学 黏弹性 激光散斑 光学检测 生物组织 

分 类 号：Q66[生物学—生物物理学]