基于稀土上转换发光纳米平台的光动力抗菌疗法的研究进展  

Research Progress on Photodynamic Antimicrobial Chemotherapy Based on Rare Earth Upconversion Nanoplatform

作　　者：赵一铭 刘成程 王晶[3] 胡敏[1] Zhao Yiming1, Liu Chengcheng2, Wang Jing3, Hu Min1(1Department of Chemistry, School of Science, Xi＇an Jiaotong University, Xi＇an, Shannxi 710049, China; 2 Department of Pathogenic Microbiology ＆ Immunology, School of Basic Medical Sciences, Xi＇an Jiaotong University Health Science Center, Xi＇an, Shannxi 710061, China; Institute of Biomedical Analytical Technology and Instrumentation, School of Life Science and Technology, Xi＇an Jiaotong University, Xi＇an, Shannxi 710049, Chin)

机构地区：[1]西安交通大学理学院化学系,陕西西安710049 [2]西安交通大学医学部基础医学院病原生物学与免疫学系,陕西西安710061 [3]西安交通大学生命科学与技术学院生物医学分析技术与仪器研究所,陕西西安710049

出　　处：《中国激光》2018年第2期171-179,共9页Chinese Journal of Lasers

基　　金：国家自然科学基金(81401710;61335012);中央高校基本科研业务费专项资金

摘　　要：稀土上转换发光纳米颗粒(UCNPs)可将近红外光转化为紫外可见光,能有效解决光动力抗菌疗法(PACT)中组织穿透深度小、治疗效率低的问题。综述了基于稀土上转换发光纳米平台的光动力抗菌疗法的研究进展,并对新型联合抗菌平台的开发及其在临床上的应用进行了展望。Rare earth upconversion nanoparticles（UCNPs）can transform near-infrared light into ultraviolet-visible light,which can effectively solve the problems such as a low tissue penetration depth and a low treatment efficiency of photodynamic antimicrobial chemotherapy（PACT）.The research progress on the photodynamic antimicrobial chemotherapy based on rare earth upconversion nanoplatforms is reviewed.The development of novel coantibacterial platform and its clinical applications are prospected.

关 键 词：医用光学 光动力抗菌疗法 稀土上转换纳米颗粒 协同治疗 多重耐药菌 

分 类 号：O43[机械工程—光学工程] Q631[理学—光学]