光学相干层析技术在血管流场检测方面的研究进展  

Research Progress on Optical Coherence Tomography in Detecting Vascular Flow Field

作　　者：高峰[1] 樊金宇 孔文[1] 史国华[1] Gao Feng1, Fan Jinyu2, Kong Wena, Shi Guohua4(Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences Suzhou, Jiangsu 215163, Chin)

机构地区：[1]中国科学院苏州生物医学工程技术研究所,江苏苏州215163

出　　处：《中国激光》2018年第2期228-240,共13页Chinese Journal of Lasers

基　　金：江苏省杰出青年基金(BK20060010);中国科学院前沿科学重点研究项目(QYZDB-SSW-JSC03);中国科学院卓越青年科学家项目;国家自然科学基金(61675226);科技部重大科学仪器设备开发专项(2016YFF0102000);万人计划青年拔尖人才项目

摘　　要：光学相干层析技术(OCT)能对生物样品进行高分辨、无损的结构成像。通过分析信号中相位或强度的变化,可将成像样品中的运动组织和静态组织区分开,进而提取样品的流场信息;总结了多种血管中血流形态信息的测量方法。OCT不需要注入其他辅助试剂即可对皮肤或眼睛的血管部位成像,逐渐成为临床上血管微循环测量的有力手段。对傅里叶OCT(FD-OCT)中基于强度或相位原理的血管检测和流场测量的6种典型方法进行综述,包括相位多普勒分辨、相位多普勒方差、基于强度的相位多普勒方差、散斑方差、分频幅去相干血管造影和光学微血管造影。在解决相位稳定、流速测量、信噪比、实时性等问题上,每种方法都有各自的优缺点。通过进一步理解成像原理,介绍了一系列的优化造影方法。最后,对这些技术的发展和应用进行了展望。Optical coherence tomography（OCT）can image the structure of the biological samples with high resolution and non-destruction.By analyzing the phase or intensity change of the signal,we can distinguish the motion tissue and the static tissue in the sampler,and then extract flow fieldfield information.Various methods are summarized to detect blood flow in blood vessel.OCT has become a powerful tool for the clinical measurement of vascular microcirculation,since it can image blood vessel in skin or retina without any auxiliary reagent.We reviewed six typical methods in Fourier OCT：phase-resolved Doppler OCT,phase-resolved Doppler variance,intensity-based Doppler variance,speckle variance,split-spectrum amplitude-decorrelation angiography,and optical micro-angiography.Each method has its own advantages and disadvantages on phase stabilization,flow rate measurement,signal-to-noise ratio,and real time.Imaging schemes are optimized based on the six methods.Finally,the prospects of OCT are included.

关 键 词：生物光学 光学相干层析技术 微血管造影 流场检测 

分 类 号：TN247[电子电信—物理电子学]