原发性高血压患者颈动脉内中膜厚度与甲状腺激素的关系  

Association of carotid artery intima-media thickness and thyroid hormone in hypertensive patients

作　　者：祝艳秋[1] 郭丽苹[1] 姜一农[2] 程云鹏[2] ZHU Yanqiu1, GU OLiping1, JIANG Yinong2, CHENG Yunpeng2(1Department of Ultrasonic, the Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China; 2 Department of Cardiology, the First Affiliated Hospital of Dalian Medical Universit)

机构地区：[1]大连大学附属中山医院超声科,辽宁大连16001 [2]大连医科大学附属第一医院心内科

出　　处：《临床心血管病杂志》2018年第3期282-285,共4页Journal of Clinical Cardiology

基　　金：辽宁省博士课题启动基金(No:210601228)

摘　　要：目的:探讨原发性高血压(EH)患者颈动脉内中膜厚度(cIMT)与甲状腺激素的相关性。方法:入选2016-01-2017-05于大连医科大学附属第一医院高血压科住院的EH患者330例,收集基础临床资料,根据cIMT分为cIMT增厚组(≥1mm)和cIMT正常组(<1mm),比较2组间甲状腺激素的水平,并分析其与cIMT之间的相关性。结果:cIMT增厚组患者年龄明显大于cIMT正常组[(61.78±10.86)岁∶(47.30±12.54)岁,P=0.000];cIMT增厚组促甲状腺激素(TSH)水平明显高于cIMT正常组[(2.23±1.26)μIU/ml∶(1.79±0.85)μIU/ml,P=0.034],而游离三碘甲状原氨酸(FT3)水平明显低于cIMT正常组[(4.96±0.60)pmol/L∶(5.25±0.57)pmol/L,P=0.012];cIMT与TSH水平呈正相关(r=0.196,P=0.041),与FT3呈负相关(r=-0.215,P=0.025);在校正年龄因素后,cIMT与TSH的相关性消失(β=0.170,P=0.078),但cIMT仍与FT3呈负相关(β=-0.213,P=0.026)。结论:FT3水平降低对于EH患者可能是促进动脉粥样硬化形成的独立危险因素。Objective： To explore the correlation between carotid intima-media thickness（clMT） and thyroid hormone in essential hypertensive（EH） patients. Method： Three hundred and thirty EH patients were recruited and divided into elMT thickening group（cIMT≥1. 0 mm,n= 147） and cIMT normal group（cIMT〈1. 0 mm,n= 183） according to the carotid artery ultrasonography examination. Background clinical data, thyroid stimulating hormone（TSH）,free triiodothyronine（FT3）, free thyroxine（FT4） were compared between the two groups, and the correlation analysis were made between the cIMT and TSH, FT3 or FT4 by Pearson correlation analysis and Logistic analysis （adjusted by age）. Result：The age and TSH level of cIMT thicken group were significantly higher than clMT normal group [（61.78 ± 10.86）years vs （47.30 ±12.54）years, （2.23 ± 1.26）μU/ml vs （1.79 ± 0.85）μU/ml, respectively; P=0. 000, 0. 034, respectively], but the FT3 level was significantly lower than the cIMT normal group [（4.96±0.60）pmol/L vs （5.25±0.57）pmol/L, P=0. 012]. The cIMT was positively correlated with TSH （r=0. 196, P=0. 041）, but negatively correlated with FT3 （r=-0. 215, P=0. 025） ; after adjusted by age, the correlation between cIMT and TSH was disappeared （β=0. 170, P=0. 078）, but the cIMT was still negatively correlated with FT3 （β=-0. 213, P=0. 026）. Conclusion：Decrease of FT3 is a possible independent risk factor for the atherosclerosis in EH patients.

关 键 词：原发性高血压 颈动脉内中膜厚度 甲状腺激素 

分 类 号：R544.1[医药卫生—心血管疾病]