啶虫脒/介孔硅缓释体系的一步法制备及其释药行为  

One-step synthesis of acetamiprid/mesoporous silica sustained release system and its release performance

作　　者：温洪坚 周新华[1,2] 周红军[1,2] 徐华[1,2] 陈铧耀[1,2] WEN Hongjian1＇2, ZHOU Xinhua1＇2, ZHOU Hongjun1＇2, XU Hua1＇2, CHEN Huayao1＇2(1.College of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, 2. Guangzhou Key Lab for Efficient Use of Agricultural Chemicals, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, Chin)

机构地区：[1]仲恺农业工程学院化学化工学院,广东广州510225 [2]仲恺农业工程学院广州市农用化学品高效利用重点实验室,广东广州510225

出　　处：《仲恺农业工程学院学报》2018年第1期30-35,共6页Journal of Zhongkai University of Agriculture and Engineering

基　　金：国家自然科学基金(21576303;21606262);广东省自然科学基金(2016A030313375)资助项目

摘　　要：采用瞬间液晶模板法一步制备负载啶虫脒/F127(分子式为(EO)106(PO)70(EO)106)的介孔硅(Mesoporous silica).利用红外光谱法(Fourier transform infrared spectroscopy,FTIR)、差式扫描量热法(Differential scanning calorimeter,DSC)、扫描电镜(Scanning electron microscope,SEM)、电子显微镜(Transmission electron microscope,TEM)和氮气吸附脱附法(Brunauer-Emmett-Teller,BET)对介孔硅的结构进行了表征,并探究了载药介孔硅的释药行为.结果表明,啶虫脒成功负载于介孔硅且以非晶相存在于介孔硅中.介孔硅在水平方向上呈高度结晶的片状结构,且属于IM-3M结构.去除模板剂后的介孔硅均呈现出典型的Ⅳ型特征和笼状孔道结构;孔径分布于3~4 nm之间,具有均一的介孔孔道.载药介孔硅的药物释放曲线动力学拟合模型与Korsmeyer-Peppas模型较为符合.The mesoporous silica loaded with acetamiprid / F127 （ （EO） 106 （ PO）70 （EO） 106 ） was pre- pared by instantaneous-liquid-crystal-template method. The structure of the samples were systematically characterized by Fourier transform infrared spectroscopy （FTIR）, Differential scanning calorimeter （DSC）, Scanning electron microscope （SEM） , Transmission electron microscope （TEM） and Brunauer- Emmett-Teller （BET）. The behavior of release of the mesoporous-siliea were also investigated. The re- suits showed that acetamiprid was successfully loaded on mesoporous silica and was present with an amor- phous phase. They have IM - 3M＇ s structure of and lamellar structures with a high degree of crystallinity in the horizontal direction. The results of N2 adsorption-desorption were showed a typical type IV-features and cage-like pore structure with a relatively uniform mesoporous channels, and the pore size distribution between 3 to 4 nm. The drug release curves of different drug-loaded mesoporous silica could be in line with by kinetic model of Korsmeyer-Peppas.

关 键 词：介孔硅 啶虫脒 一步法 药物释放 

分 类 号：TQ450.6[化学工程—农药化工]