稳定期慢性阻塞性肺疾病患者去脂体质量指数与BODE指数的相关性研究  

Study of the relationship between fat-free mass index and BODE index in patients with stable chronic obstructive pulmonary disease

作　　者：吴振云[1] 钮美娥[1] 韩燕霞[1] 钱红英[1] 张媛媛[1] 张秀琴[1] 王翎[1] Wu Zhenyun, Niu Meile, Han Yanxia, Qian Hongying, Zhang Yuanyuan, Zhang Xiuqin, Wang Ling.(Department of Respiratory Medicine, the First Affiliated Hospital of Soochow University, Suzhou 215000, Chin)

机构地区：[1]苏州大学附属第一医院呼吸科,215000

出　　处：《国际呼吸杂志》2018年第5期341-345,共5页International Journal of Respiration

基　　金：苏州市科教兴卫青年科技项目（KJXW2016009）

摘　　要：目的评估稳定期慢性阻塞性肺疾病（COPD）患者去脂体质量指数（FFMI）与BODE多维评价体系（BODE指数）间的联系，探讨FFMI对评价稳定期COPD患者预后的可靠性。方法113例稳定期COPD患者进行身体成分分析及BODE指数评估，对BODE指数总分及各项与FFMI间的相关性比较，分析FFMI对评估COPD患者不良预后风险的可靠性。结果稳定期cOPD患者FFMI水平为（17．48±1．88）kg／m^2，BODE指数水平为2（1，3），FFMI与BODE呈中度相关（r=-0．425，P〈0．01），FFMI预测的最佳截点值为16．79kg／m^2，此时受试者工作特征曲线曲线下面积为0．786。结论稳定期COPD患者FFMI与BODE指数间存在良好的相关性，FFMI可间接预测稳定期COPD患者不良预后风险。Objective To assess the relationship between fat-flee mass index （FFMI） and body mass index, degree of air-flow obstructive, dyspnea, exercise capacity （BODE index） in patients with stable chronic obstructive pulmonary disease （COPD）. To investigate the reliability of FFMI for evaluating the prognosis of patients with stable COPD. Methods One hundred and thirteen patients with COPD were examined with body composition and BODE index. We compared the correlation between the FFM1 and the BODE index. We analyzed the reliability of FFMI for evaluating the prognosis of patients. Results The FFMI was （17. 484± 1.88） kg/m^2 , BODE index was 2 （1,3）, FFMI showed a moderate correlation （ r = -0. 425, P 〈0.01） with BODE, and the optimal cut-off of FFMI was 16.79 kg/me. According to the receiver operating characteristic curves, area under the curve was 0.786. Conclusions There is a good correlation between the FFMI and the BODE index in patients with COPD. FFMI can indirectly predict the risk of adverse outcomes in patients with stable COPD.

关 键 词：慢性阻塞性肺疾病 去脂体质量指数 BODE指数 截点值 

分 类 号：R563.9[医药卫生—呼吸系统]