尤瑞克林注射剂联合阿司匹林肠溶片治疗大面积脑梗死的临床研究  

Clinical trial of urinary kallidinogenase injection combined with aspirin enteric-coated tablets in the treatment of massive cerebral infaction

作　　者：蔡俊颖[1] 李国前[1] 陈渊洁 CAI Jun - ying, LI Guo - qian, CHEN Yuan - jie(Department of Neurology, Quanzhou First Affiliated Hospital of Fujian Medical College, Quanzhou 362000, Fujian Province, Chin)

机构地区：[1]福建医科大学附属泉州第一医院神经内科,福建泉州362000

出　　处：《中国临床药理学杂志》2018年第6期615-617,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察尤瑞克林注射剂联合阿司匹林肠溶片治疗大面积脑梗死的临床疗效及安全性。方法将60例首次急性大面积脑梗死患者随机分为对照组30例和试验组30例。对照组予以阿司匹林每次0.1 g,qd,口服;试验组在对照组治疗的基础上,予以尤瑞克林每次0.15 PNA,qd,静脉滴注。2组患者均治疗14 d。比较2组患者的临床疗效、美国国立卫生研究院卒中量表评分(NIHSS)、平均血流速度,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为93.33%(28例/30例)和56.67%(17例/30例),差异有统计学意义(P<0.05)。治疗后,试验组和对照组的NIHSS评分分别为(5.10±4.32)和(8.27±7.57)分,左侧大脑中动脉平均血流速度分别为(60.52±17.22)和(48.57±10.74)cm·s^(-1),右侧大脑中动脉平均血流速度分别为(59.48±16.87)和(50.70±7.22)cm·s^(-1),差异均有统计学意义(均P<0.05)。试验组的药物不良反应主要有颜面潮红、头痛、注射部位红痒等,对照组的药物不良反应主要有头痛和恶心。试验组和对照组的总药物不良反应发生率分别为13.33%和10.00%,差异无统计学意义(P>0.05)。结论尤瑞克林注射剂联合阿司匹林肠溶片治疗大面积脑梗死的临床疗效确切,其能显著改善患者的脑血流动力学,且不增加药物不良反应的发生率。Objective To observe the clinical efficacy and safety of urinary kallidinogenase injection combined with aspirin enteric -coated tablets in the treatment of massive cerebral infaction. Methods Sixty patients with massive cerebral infaction were randomly divided into control and treatment groups with 30 cases per group. Control group was given aspirin 0. 1 g per time, qd, orally. Treatment group was received urinary kallidinogenase 0. 15 PNA per time, qd, intravenous infusion, on the basis of control group. Two groups were treated for 14 d, The clinical efficacy, nationa institute of health stroke scale （NIHSS）, mean blood velocity and adverse drug reactions were compared between two groups. Results After treatment, the total effective rates in treatment and control groups were 93.33% （28 cases/30 cases） and 56. 67% （17 cases/ 30 cases） with significant difference （ P 〈 0. 05 ）. After treatment, the main indexes in treatment and control groups were compared： NIHSS scores were （5. 10 ±4. 32） and （8.27 ±7.57） points, the mean blood velocity of left middle artery were （60.52 ±17.22 ） and （48.57±10.74）cm·s-1, the mean blood velocity of right middle artery were （ 59.48 ± 16. 87 ） and （50. 70 ± 7.22 ）cm·s -1, with significant differences （ all P 〈 0. 05 ）. The adverse drug reactions in treatment group were facial blushing, headache and tickle in the injection site, which in control group were headache and vomiting. The incidences of adverse drug reactions in treatment and control groups were 13.33% and 10. 00% without significant difference （P 〉 0. 05 ）. Conclusion Urinary kallidinogenase injection combined with aspirin enteric - coated tablets has a definitive clinical efficacy in the treatment of massive cerebral infaction, which can improve the hemodynamics, without increasing the incidence of adverse drug reactions.

关 键 词：尤瑞克林注射剂 阿司匹林肠溶片 大面积脑梗死 脑血流 安全性 

分 类 号：R972[医药卫生—药品]