VEGF在子宫内膜息肉的表达及口服避孕药对其的下调作用  

Expression of VEGF in endometrial polyps and down - regulation of oral contraceptive

作　　者：黄晓晖[1] 和秀魁[1] 黄彩彩[1] 徐丽群 Huang Xiaohui, He Xiukui, Huang Caicai, Xu Liqun(Department of Gynecology, Guangdong Women and Children＇s Hospital Guangzhou 510010, Chin)

机构地区：[1]广东省妇幼保健院妇科,广州510010

出　　处：《国际医药卫生导报》2018年第5期632-634,共3页International Medicine and Health Guidance News

基　　金：广东省科技计划项目（2014A020212553）

摘　　要：目的通过测定子宫内膜息肉（EP）中血管内皮生长因子（VEGF）的表达，从血管生成机制方面研究EP发生发展机理，为临床预防EP复发治疗提供实验依据。方法选取2015年6月至2016年6月在本院行宫腔镜下EP刮除术，并且病理确诊为EP的病例30例作为研究组（EP组织组、EP旁内膜组），取同期因不孕不育行宫腔镜检查而镜下及诊刮内膜病理未见异常的病例共30例作为对照组（正常子宫内膜组）。用免疫组织化学方法测定EP患者EP组织、EP旁内膜和正常子宫内膜中VEGF的表达情况。研究组术后服用屈螺酮炔雌醇治疗3个周期后再次检测子宫内膜中VEGF的表达。结果VEGF的表达阳性率情况：EP组织组（73．33％）〉EP旁内膜组（46．67％）〉正常子宫内膜组（20．00％），差异有统计学意义（P〈0．05）；用口服避孕药（COC）治疗3个周期后，EP患者子宫内膜组织中VEGF的表达阳性率由46．67％下降至16．67％，差异有统计学意义（P〈0．05）。结论VEGF的表达增加、微血管生成增加可能是EP形成的原因，COC治疗可下调子宫内膜组织中VEGF的表达，对预防EP术后复发有一定作用。Objective To detect the expression of vascular endothelial growth factor （VEGF） in endometrial polyps （EP）, to explore its mechanism based on the mechanism of angiogenesis, and to provide experimental evidence for clinical treatment. Methods 30 patients pathologically confirmed as EP who underwent hysteroscopic resection of EP in our hospital from June 2015 to June 2016 were selected as the study group, and 30 patients who underwent hysteroscopy because of infertility and pathologically confirmed as normal endometrium during the same period were selected as the control group. The expression of VEGF in EP tissue and adjacent zone to the EP of the study group, and control group were measured by immunohistochemistry. The study group was treated with drospirenone and ethinylestradiol for 3 cycles, and then the expression of VEGF in the endometrium was detected again. Results The positive expression rate of VEGF： EP tissue （73.33%） 〉 adjacent zone to the EP （46.67%） 〉 normal endometrium （20.00%） （P〈0.05）. After 3 cycles of COC treatment, the positive expression rate of VEGF in adjacent zone to the EP of EP patients was down-regulated from 46.67% to 16.67% （P〈0.05）. Conclusions Increased expression of VEGF leading to increased microvascular angiogenesis may be one of the reasons of the formation of ER COC treatment can reduce the expression of VEGF in endometrial tissue, and thus has a certain role in preventing relapse of EP.

关 键 词：子宫内膜息肉 VEGF 口服避孕药 

分 类 号：R711.74[医药卫生—妇产科学]