高血压对帕金森病伴脑白质病变患者运动功能的影响  

Effect of hypertension on motor function in Parkinson's disease patients with white matter lesion

作　　者：彭泽艳 董舒阳 陶永[2] 霍颖超[2] 周华东[2] Peng Zeyan, Dong Shuyang, Tao Yong, Huo Yingchao, Zhou Huadong(Bengbu Medical College Postgraduate School , Bengbu 233030 ,Anhui Province ,Chin)

机构地区：[1]蚌埠医学院研究生院,233030 [2]第三军医大学大坪医院神经内科

出　　处：《中华老年心脑血管病杂志》2018年第3期286-289,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：蚌埠医学院研究生科研创新计划(Byycx1613)

摘　　要：目的探讨高血压对帕金森病(Parkinsons disease,PD)伴脑白质病变(white matter lesions,WML)患者运动功能的影响。方法选择2015年1月~2016年1月在我院就诊的PD伴WML患者219例,随访1年结束后,根据患者是否出现运动功能下降,将患者分为运动功能下降组137例及无运动功能下降组82例。分析各血管危险因素和各级高血压与PD伴WML患者运动功能下降的关系。结果与无运动功能下降组比较,运动功能下降组患者年龄高、收缩压、舒张压高、糖尿病、高脂血症、高血压发生率明显升高(P<0.05,P<0.01)。logistic多因素回归分析显示,年龄(OR=1.78,95%CI:1.43~2.14)、高血压(OR=1.97,95%CI:1.49~2.52)及糖尿病(OR=1.63,95%CI:1.31~1.94)与PD伴WML患者出现运动功能下降的风险明显相关。进一步分析发现,2级和3级高血压与PD伴WML患者运动功能下降的风险有明显相关性(OR=1.62,95%CI:1.29~1.95;OR=2.19,95%CI:1.49~2.91)。结论高血压可能会加重或引起PD伴WML患者的运动功能下降,尤其是2级和3级高血压。Objective To study the effect of hypertension on motor function in Parkinson＇s disease（PD）patients with white matter lesion（WML）.Methods Two hundred and nineteen PD patients with WML were divided into hypokinesia group（n=137）and non hypokinesia group（n=82）.The patients were followed up for 1 year.The relationship of vascular risk factors with hypertension and hypokinesia was analyzed.Results The age was older,the incidence of hypertension,DM and lipidemia was higher,the SBP and DBP were higher in hypokinesia group than in non hypokinesia group（P0.01,P0.05）.Logistics regression analysis showed that age,hypertension and DM were the risk factors for hypokinesia in PD patients with WML（OR=1.78,95%CI：1.43-2.14,OR=1.97,95%CI：1.49-2.52,OR=1.63,95%CI：1.31-1.94）.Further analysis showed that grade 2 and 3 hypertension were closely related the risk of hypokinesia in PD patients with WML（OR=1.62,95%CI：1.29-1.95;OR=2.19,95%CI：1.49-2.91）.Conclusion Hypertension,especially grade 2 and 3 hypertension,can aggravate hypokinesia in PD patients with WML.

关 键 词：高血压 帕金森病 运动障碍 糖尿病 高脂血症 脑白质疏松症 

分 类 号：R544.1[医药卫生—心血管疾病] R742.5[医药卫生—内科学]