不同DRD2基因型的海洛因成瘾者抑制性控制功能的fMRI研究  

The fMRI study of brain inhibitory control function difference between DRD2 gene subtype of heroin addicts

作　　者：李小怀 王亚蓉 李玮 李强 李永斌 陈佳杰 叶建军 张东升 王玮 LI Xiaohuai,WANG Yarong,LI Wei,LI Qiang,LI Yongbin,CHEN J iajie,YE Jianjun,ZHANG Dongsheng,WANG Wei ＊(Department of Radiology, Tangdu Hospital,the Air Force Military Medical University, Xi＇an 710038,Chin)

机构地区：[1]空军军医大学唐都医院放射科,陕西西安710038

出　　处：《实用放射学杂志》2018年第3期329-333,共5页Journal of Practical Radiology

基　　金：国家自然科学基金（81471648）.

摘　　要：目的 探讨不同DRD2基因型的海洛因成瘾者抑制性控制功能的差异。方法 根据DRD2 基因型将37例单纯海洛因成瘾者分为DRD2 Taq IA＋型组（A＋组，22例）和DRD2 Taq IA－型组（A－组，15例），两者间人口学特征、海洛因使用情况相匹配。被试者执行事件相关go/nogo任务的同时进行3.0T fMRI扫描，随后记录被试者1年内每月吗啡尿检阳性次数，使用SPM8和SPSS16.0软件进行fMRI和行为学数据处理。结果 2组间被试者反应时间、正确率、nogo错误率差异均无统计学意义（P＞0.05）。与A－组相比，A＋组双内侧前额叶、背侧前扣带、中扣带、辅助运动区、颞叶、梭状回、舌回、距状回、海马及海马旁回等脑区激活减弱；未发现激活增强的脑区（体素值＞228，t=2.11，Alphasim校正，P＜0.05）。各脑区激活强度与海洛因使用情况、吗啡尿检阳性次数均未发现明显相关性（P＞0.05）。结论 DRD2 Taq IA基因的A＋型较其等位基因A－型存在记忆、抑制性控制、视觉空间注意力的多种功能脑区的激活减弱，这可能是A＋基因型携带者易成瘾和复吸的神经基础。Objective To explore the difference in inhibitory control ability between DRD2 gene subtype of heroin addicts with fMRI.Methods Thirty-seven heroin-dependent patients were divided into DRD2 Taq IA＋ group （A＋, 22） and matched DRD2 Taq IA--group （A-, 15）. Functional MRI was performed in all patients while they were executing an event-related go/nogo task at 3.0T MR scanner. The differences of brain activated images and behavioral data between the two groups were analyzed with SPM8 and SPSS16.0 software,respectively.Results There were no significant differences in reaction time,accuracy and false alarm rates between the two groups （P〉0.05）.Compared with A-group,weaker activation in the medial prefrontal cortex, dorsal anterior cingulate, middle cingulate, supplementary motor area, temporal lobe, fusiform gyrus, lingual gyrus, hippocampus and parahippocampal gyrus in response inhibition condition were demonstrated in A ＋ group （ voxel number~ 228, t = 2.11, Alphasim correction, P〈 0.05）. There was no corrlation between the intensity within the activated brain regions and the usage of heroin,morphine urine test positive number（P〉0.05）.Conclusion DRD2 Taq IA＋ group exist deactivation of the brain area on memory, inhibitory control, visual spatial attention. It may be the neural basis that contribute to easy addiction and relapse for A＋ carriers.

关 键 词：DRD2基因 抑制性控制 磁共振成像 

分 类 号：R996[医药卫生—毒理学] R445.2[医药卫生—药学]