复元醒脑方与活血通腑方对患者血浆神经肽Y和神经降压素的含量变化的影响  

Effects of “Fuyuan-Xingnao” and “Huoxue-Tongfu” Therapy on Content Change of Neuropeptide Y and Neurotensin in Patients

作　　者：黄孟辛 黎春镛 HUANG Meng-xin1, LI Chun-yong2(1. Department of Encephalopathy, Guangzhou Conghua District Hospital of Traditional Chinese Medicine, Guangzhou, 510900, China; Internal Medicine-Neurology, General Hospital of Guangzhou Military Region, Guangzhou, 510000, Chin)

机构地区：[1]广州市从化区中医医院脑病科,广东广州510900 [2]广州军区总医院神经内科,广东广州510000

出　　处：《成都中医药大学学报》2018年第1期56-59,共4页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：国家中医药管理局立项(JDZX2012074)

摘　　要：目的:探讨复元醒脑与活血通腑治疗对急性脑出血患者血浆神经肽Y和神经降压素的含量变化的影响。方法:采用随机数字法将75例急性脑出血患者随机分成3组:常规治疗组(A组,n=25)、常规治疗联合复元醒脑方治疗组(B组,n=25)、常规治疗联合活血通腑方治疗组(C组,n=25),治疗时间为1个月。比较3组受试者治疗后脑水肿面积与血肿体积;分别采用GCS评分、NIHSS评分评价组3组受试者治疗前后意识程度以及神经功能缺损程度;采用放射免疫法测定组3组受试者治疗前后血浆神经肽Y以及神经降压素含量。结果:治疗后,3组受试者脑水肿面积、血肿体积、GCS评分、NIHSS评分较治疗前均发生明显改善,改善幅度由大到小依次为B组、C组、A组,3组间差异具有统计学意义(P<0.05);治疗后,3组受试者血浆神经肽Y以及神经降压素含量较治疗前均发生明显下降,下降幅度由大到小依次为B组、C组、A组,3组间差异具有统计学意义(P<0.05)。结论:在常规治疗的基础上结合复元醒脑与活血通腑2种中医方案有利于改善急性脑缺血患者的血浆神经肽Y与神经降压素水平,提高治疗效果,且复元醒脑法效果更优。Objective： To explore the effects of ＂Fuyuan-xingnao＂ and ＂Huoxue-tongfu＂ therapy on the content change of neuropeptide Y and neurotensin in patients. Methods： 75 patients with acute cerebral hemorrhage were randomly divided into three groups by random number method, routine treatment group （group A, n = 25）, routine treatment combined with ＂Fuyuan-xingnao＂ treatment group （group B, n = 25）, routine treatment combined with ＂Huoxue-tongfu＂ treatment group （ group C, n = 25 ）, the treatment time was 1 month. The cerebral edema erea and hematoma volume were compared after the treatment; GCS score and NIHSS score were used to evaluate the degree of consciousness and the neurologic impairment before and after the treatment; Radi ty was used to determine the content of neuropeptide Y and neurodetensin before and after the treatment. Results： After the treatment, the brain e- dema area, hematoma volume, GCS score and NIHSS score of the three groups were obviously improved, the improvement range from large to small was group B, group C and group A, which showed statistical significance among the three groups （P 〈 0. 05） ; After the treatment, the content of plasma neuropeptide Y and neurodetensin of the three groups were significantly lower, the decrease from big to small was group B, group C and group A, which showed statistically significance among the three groups （ P 〈 0. 05 ）. Conclusion： On the basis of routine treatment combined with ＂Fuyuan-xingnao＂ and ＂Huoxue-tongfu＂ of TCM is helpful to improve the levels plasma neuropeptide Y and neurotensin of the patients with acute cerebral ischemia and can improve the clinical effects, and the method of ＂Fuyuan-xingnao＂ is more effective.

关 键 词：复元醒脑 活血通腑 神经肽Y 神经降压素 

分 类 号：R242[医药卫生—中医临床基础] R322.8[医药卫生—中医学]