软坚化癥汤治疗乳腺增生肝郁痰凝证疗效观察  

Clinical Study of Ruanjian Huazheng Tang in Treating Hyperplasia of Mammary Gland with Liver Stagnation and Phlegm Coagulation Syndrome

作　　者：张红霞[1] 刘莲[1] 郑宏[1] 王瑜玲[1] 吴宗耀[1] ZHANG Hongxia, LIU Lian, ZHENG Hong, WANG Yuling, WU Zongyao(The Fifth Hospital of Shijiazhuang, Shijiazhuang Hebei China 05002)

机构地区：[1]石家庄市第五医院,河北石家庄050021

出　　处：《中医学报》2018年第2期307-310,共4页Acta Chinese Medicine

基　　金：河北省科技成果重点推广计划(2016112)

摘　　要：目的:观察软坚化癥汤治疗乳腺增生肝郁痰凝证的临床疗效。方法:将140例乳腺增生肝郁痰凝证患者随机分为对照组和观察组,每组70例。对照组采用常规的枸橼酸他莫昔芬片口服治疗,观察组采用软坚化癥汤[莪术、红花、桃仁、生牡蛎、海藻、三棱、柴胡、青皮(醋制)、山慈菇、冰片、丹参、延胡索、香附(醋制)、王不留行(炒制)、鳖甲(醋制)、夏枯草]治疗。观察两组治疗前后孕酮、雌二醇水平变化;乳房增生区血流参数、血流阻力指数;证候积分变化情况;及停药3个月后观察两组患者的临床疗效。结果:停药3个月后两组患者的临床疗效比较,治疗组有效率为91.42%,对照组有效率为82.86%,差异有统计学意义(P<0.05)。治疗后乳房肿块硬度积分、疼痛积分及伴随症状积分均明显降低,差异均有统计学意义(P<0.05)。治疗后,观察组血清孕酮水平提高,血清雌二醇水平均降低,差异均有统计学意义(P<0.05)。治疗组血流阻力指数低于对照组,差异有统计学意义(P<0.05)。结论:软坚化癥汤治疗乳腺增生肝郁痰凝证疗效显著,且能够有效改善患者的中医证候积分、增强激素调节作用,降低血流阻力、促进增生乳房的血液循环,提高患者的生存质量,且无不良反应。Objective：To observe the clinical effect of Ruanjian Huazheng Tang in treating hyperplasia of mammary gland with liver stagnation and phlegm coagulation syndrome.Methods：140 cases of hyperplasia of mammary gland with liver stagnation and phlegm coagulation syndrome were randomly divided into the control group and the observation group with 70 cases in each group.The control group was given routine oral tamoxifen citrate tablets.The observation group was treated with Ruanjian Huazheng Tang,the composition：Ezhu（Rhizoma Curcumae）,Honghua（Safflower）,Taoren（Peach Kernel）,Shengmuli（Raw Oysters）,Haizao（Seaweed）,Sanleng（Rhizoma Sparganii）,Chaihu（Bupleurum）,Qingpi（Green Tangerine Peel,vinegar-process）,Shancigu（Pseudobulbus Cremastrae Seu Pleiones）,Bingpian（Borneol）,Danshen（Salvia Miltiorrhiza）,Yanhusuo（Rhizoma Corydalis）,Xiangfu（Rhizoma Cyperi,vinegar-process）,Wangbuliuxing（Cowherb Seed,Frying）,Biejia（Turtle Shell,vinegar-process）,Xiakucao（Selfheal）.Observed the changes of progesterone and estradiol levels in two groups were before and after treatment.Observed parameters of blood flow in proliferative area of breast,blood flow resistance index,the change of syndromes integral,and clinical effects of the two groups 3 months after therapy.Results：Three months after withdrawal,the effective rate was 91.42% in the treatment group and 82.86% in the control group,and the difference was statistically significant（P0.05）.After treatment,breast lumps hardness integral,pain score and associated symptom score were significantly decreased（P0.05）.After treatment,in the observation group,the level of serum progesterone was increased and the level of estradiol in serum was decreased,the difference was statistically significant（P0.05）.The index of blood flow resistance was lower than that of the control group（P0.05）.Conclusion：Ruanjian Huazheng Tang in treating hyperplasia of mammary gland with liver stagnation and phlegm coagulation syndrome has sig

关 键 词：乳腺增生 肝郁痰凝证 软坚化癥汤 中医药疗法 中西医结合 

分 类 号：R269.558[医药卫生—中西医结合]