独活寄生汤治疗膝骨性关节炎作用机制的现代药理学研究进展  

Modern pharmacology research progress on the mechanism of Duhuo Jisheng Decoction in the treatment of knee osteoarthritis

作　　者：苏晓琳[1] 王江威 赵婉[1] 杨炳友[1] 匡海学[1] 王秋红[1,2] SU Xiaolin;WANG Jiangwei;ZHAO Wan;YANG Bingyou;KUANG Haixue;WANG Qiuhon(Key Laboratory of North Medicine Base and Application, Ministry of Education, Heilongjiang University of Chinese Medicine Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material Bases, Heilongjiang Province, Harbin 150040, China;College of Chinese Medicine, Guangdong Pharmaceutical University, Guangdong Province, Guangzhou 510006, China)

机构地区：[1]黑龙江中医药大学北药基础与应用研究教育部重点实验室黑龙江省中药及天然药物药效物质基础研究重点实验室,黑龙江哈尔滨150040 [2]广东药科大学中药学院,广东广州510006

出　　处：《中国医药导报》2018年第7期36-39,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81773904;81473351);黑龙江中医药大学科研基金项目(201720)

摘　　要：独活寄生汤是应用于骨伤科类疾病的常用方剂,治疗膝骨性关节炎尤为广泛。笔者总结近十余年中外文献,对其治疗的作用机制进行分类、总结,发现该方剂不仅可以抑制炎症因子,影响氧化应激指标,而且在抑制基质金属蛋白酶、抑制软骨细胞凋亡、增加软骨胶原含量、影响微小RNA表达等方面发挥作用。随着其作用机制研究的不断深入,不但能拓宽该方剂的使用范围,而且能更清晰地指导临床医师精准用药。Duhuo Jisheng Decoction is a common formula for curingorthopedic diseases, which is particularly extensive in the treatment of knee osteoarthritis. The author summarizes literatures at home and abroad in the nearly ten years, classifies and sums up the treatment mechanism, and finds that the formulae not only can inhibit inflammatory cy- tokines and affects oxidative stress indicators, but also plays an important role in the inhibition of matrix metallopro- teinase, inhibition of chondrocyte apoptosis, increasing cartilage collagen content and influencing the expression of mi- croRNA. With the further research of the mechanism, it can not only broaden the use of the formula, but also guide clinicians to use precise formula more clearly.

关 键 词：膝骨性关节炎 独活寄生汤 作用机制 研究进展 

分 类 号：R684.3[医药卫生—骨科学]