新诊断2型糖尿病患者胰岛素泵基础量与BMI、HbA1c的相关性分析  

Correlation Analysis of Insulin Pump Base Amount and BMI, HbAlc in Patients with Newly Di- agnosed Type 2 Diabetes

作　　者：黄国圣[1] 张锦明[2] 赵玲[2] 宋薇[2] HUANG Guo sheng, ZHANG Jin-ming, ZHAO Lin,et al(Department of Cardiovascular, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510145,China)

机构地区：[1]广东省中医院心血管科,广东广州510145 [2]广东省中医院内分泌科,广东广州510145

出　　处：《医学临床研究》2018年第3期498-500,共3页Journal of Clinical Research

摘　　要：【目的】探讨新诊断2型糖尿病（T2DM）患者初始胰岛素泵强化治疗基础量与体质指数（BMI）、糖化血红蛋白（HbA1c）的相关性。【方法】选择2015年1月至2017年6月广东省中医院内分泌科住院并行胰岛素泵强化治疗的新诊断T2DM患者93例，收集患者的一般资料，计算BMI、腰臀比（WHR），采用全自动生化分析仪检测血清生化指标，应用高效液相色谱法（HPLC）检测全血HbA1C水平，监测治疗期间空腹血糖（FPG）和餐后2h血糖（2hPG）水平，并对胰岛素泵强化治疗血糖达标时胰岛素泵基础量与临床指标进行相关性分析。【结果】经胰岛素泵强化治疗后血糖达标者72例，未达标者21例。血糖达标组患者的BMI、胰岛素泵总量、胰岛素泵基础量、HbA1c、FPG、2hPG显著低于血糖未达标组（P〈0．05）。胰岛素泵强化治疗血糖达标时胰岛素泵基础量与病程、BMI、FPG、2hPG、高密度脂蛋白胆固醇（HDL-C）呈正相关（均P〈0．05），与低密度脂蛋白胆固醇（LDL—C）呈负相关（P〈0．05），与年龄、WHR、HbA1c、胆固醇（TC）、三酰甘油（TG）均无相关性（均P〉0．05）。【结论】对于新诊断T2DM患者，BMI与初始胰岛素泵治疗的基础量存在相关性，可作为胰岛素泵基础量的参考指标之一。[Objective]To investigate the correlation between the basic amount of initial intensive insulin pump therapy and body mass index （BMI）, glycosylated hemoglobin （HbAlc） in patients with newly diag- nosed type 2 diabetes mellitus （T2DM）. [Methods]From January 2015 to June 2017, 93 newly diagnosed T2DM patients in Department of Endocrinology, Guangdong Provincial Hospital of traditional Chinese Medi cine, receiving intensive insulin pump therapy, were selected, and the general data of the patients were collect- ed. BMI and WHR were calculated. Serum biochemical indexes were detected by automatic biochemical analy- zer, whole blood HbAlc was measured by HPLC, fasting blood glucose （FBG） and 2 h postprandial blood glucose （2hPGG） were monitored during treatment. The correlation between the basic quantity of insulin pump and clinical index was analyzed.[Results]After intensive treatment with insulin pump, 72 patients reached the standard of blood glucose and 21 patients failed to reach the standard. The BMIs, the total amount of insulin pump and the basic quantity of insulin pump were significantly lower than those in the substandard group （ P 〈0.05）. There was a positive correlation between the basal insulin pump level and the course of BMI , FPG, 2hPG and HDL-C （mean P 〈0.05）, and a negative correlation with low density lipoprotein cholesterol （LDL- C） （ P 〈0.05）, and no correlation with age ,WHR, HbAlc, TC, TGs （mean P 〉0.05）.[Conclusion]For patients newly diagnosed with type 2 diabetes, BMI is associated with the basal volume of initial insulin pump therapy and can be used as a reference indicator of basal insulin pump volume.

关 键 词：糖尿病 2型 胰岛素输注系统 人体质量指数 血红蛋白A 糖基化 

分 类 号：R587.1[医药卫生—内分泌]