小儿肺热咳喘颗粒清热解毒、止咳平喘作用研究  

Study on efficiencies of heat-clearing,detoxicating,antitussive and antiashmatic for Xiaoer Feire Kechuan Particles

作　　者：杜芬芬 霍璇 冯玥[2,3] 申秀萍 刘全国[4] 应森林 胡金芳[2,3] DU Fen-fen1, HUO Xuan2, 3, FENG Yue2, 3 SHEN Xiu-ping2, 3 Liu Quan-guo4, YING Sen-lin1, HU Jin-fang2, 3(1. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 2. Tianjin Engineering Research Center of drug preclinical assessment technology Tianjin 300301, China 3. Tianjin Institute of Pharmaceutical Research New Drug Evaluation Co., Ltd., Tianjin 300301, China 4. Hainan Huluwa Pharmaceutical Group Co. Ltd., Haikou 570100, Chin)

机构地区：[1]天津中医药大学,天津300193 [2]天津市新药非临床评价技术工程中心,天津300301 [3]天津药物研究院新药评价有限公司,天津300301 [4]海南葫芦娃药业集团股份有限公司,海南海口460105

出　　处：《药物评价研究》2017年第12期1706-1710,共5页Drug Evaluation Research

基　　金：国家科技重大新药创制项目(2015ZX09501004);天津市科技计划项目(16PTGCCX00090)

摘　　要：目的研究小儿肺热咳喘颗粒(XFKP)清热解毒、止咳平喘作用。方法采用牛奶致热家兔模型观察XFKP的解热作用;制备脂多糖(LPS)肺炎小鼠模型,观察XFKP对支气管肺泡灌洗液中超氧化物歧化酶(SOD)、髓过氧化物酶(MPO)活性及炎症细胞的积聚的影响;采用小鼠氨水、豚鼠磷酸组胺诱咳引喘模型,观察XFKP的止咳平喘作用。结果与对照组比较,高、中剂量XFKP能够显著降低发热家兔体温(P<0.05);高、中剂量XFKP明显降低肺炎模型小鼠肺内积水量和肺泡中白细胞总数、淋巴细胞数,且高剂量组能显著抑制MPO活性(P<0.05、0.01);高、中剂量XFKP组能够显著地延长小鼠咳嗽潜伏期,减少咳嗽次数,延长豚鼠引喘潜伏期(P<0.05、0.01)。结论小儿肺热咳喘颗粒具有显著的清热解毒、止咳平喘作用。objective To study the efficiencies of heat-clearing, detoxicating, antitussive, and antiashmatic for Xiaoer Feire Kechuan Particles（XFKP）. Methods The heat-clearing, detoxicating effects were investigated in the rabbits and mice models induced by milk and lipolysaccharide（LPS）, respectively. Moreover, the activities were detected for SOD, MPO and the numbers of inflammatory cells were also counted in bronchoalveolar lavage fluid from mice model. Also, the models were induced by ammonia and phosphoric acid histamine in mice or guinea pigs to observe the cough suppression and relieving asthma of XFKP. Results Compared with control group, XFKP with high and medium dose groups significantly lowered the temperature of rabbits＇ model（P〈0.05）; XFKP with high and medium dose groups obviously reduced the fluid in the lungs of mice pneumonia model and total number of pulmonary alveolar leukocytes and lymphocytes, and significantly prolonged the cough incubation period in mice model to reduce the times of cough and the asthma incubation period in guinea pigs model（P〈0.05 or 0.01）. Additionally, the high dose group inhibited the activity of MPO（P〈0.05）, conspicuously. Conclusion In this paper, the efficiencies of heat-clearing, detoxicating, antitussive and antiashmatic for Xiaoer Feire Kechuan Particles were confirmed.

关 键 词：小儿肺热咳喘颗粒 清热 解毒 止咳 平喘 

分 类 号：R965.1[医药卫生—药理学]