卡前列素氨丁三醇注射液治疗前置胎盘剖宫产产后出血的临床效果观察  

Hemabate combined with Iodoform gauze packing in uterine cavity in treating placenta previa of clinical effect observation

作　　者：范丽丽[1] 薛秀珍[1] 张镛镛[1] 焦娜[1] FAN Li-li, XUE Xiu-zhen, ZHANG Yong-yong, JIAO Na(Obstetrical Department, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, Chin)

机构地区：[1]河南科技大学第一附属医院产科,河南洛阳471000

出　　处：《药物评价研究》2017年第12期1770-1772,共3页Drug Evaluation Research

摘　　要：目的探讨卡前列素氨丁三醇注射液治疗前置胎盘剖宫产产后出血的临床效果。方法根据医院数据库的记录随机选取2015年1月—2016年6月,河南科技大学第一附属医院收治的65例前置胎盘剖宫产患者作为研究对象,根据治疗方法分成观察组和对照组,观察组患者33例,对照组患者32例。胎儿娩出后,胎盘存在粘连、植入,胎盘剥离面广泛渗血,出血量大于500 m L时,对照组以宫腔填塞碘仿纱条行止血治疗,观察组患者则在对照组治疗的方法基础上,在填塞碘仿纱条的过程中在子宫壁注射卡前列素氨丁三醇注射液250μg,若患者仍有产生出血现象,可在0.5 h时后行1次注射,但是总注射剂量应在2 mg以下。宫纱放置用时为48 h,取纱前的30 min对其静脉滴注缩宫素。综合比较两组患者产后出血量的改变情况、子宫切除率和治疗前后的收缩压、舒张压、脉搏跳动以及血氧饱和度的情况。结果观察组患者产后2 h、产后24h的出血量分别为(380.12±12.77)、(461.48±13.33)m L,均少于对照组患者的(952.34±111.65)、1160.7±132.87)m L,差异有统计学意义(P<0.05)。观察组子宫的切除率为0%,对照组的子宫切除率为9.38%,观察组的子宫切除率低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后收缩压、舒张压较治疗前无明显下降,脉搏次数、血氧饱和度治疗前后提升也不大,组间比较差异无统计学意义。结论卡前列素氨丁三醇注射液治疗前置胎盘剖宫产产后出血效果明显,能够很好地控制患者产后的出血量,治疗安全性良好,值得推广。Objective Discuss the clinical effect observation Hemabate combined with Iodoform gauze packing in uterine cavity in treating placenta previa. Methods Retrospective analysis 65 cases patients with placenta previa inspection data from our hospital during January 2015 to June 2016, the patients will be selected by random number table method is divided into research group and the control group, the research goups have 33 patients and the control groups have 32 patients. Control group on the basis of the conventional treatment methods with odoform gauze packing in uterine cavity, the research group on the basis of the control group used Hemabate treatment, compared two groups of patients with intraoperative, Uterus resection rate, before and after treatment of systolic pressure, diastolic blood pressure, pulse and blood oxygen saturation. Results The research Group patients after 2 h, 24 h of postpartum haemorrhage amount respectively（380.12 ± 12.77）,（461.48 ± 13.33） m L, less than the control group patients after 2 h, 24 h of postpartum haemorrhage amount respectively（952.34 ± 111.65） m L,（1160.7 ± 132.87） m L, the difference was statistically significant（P〈0.05）, uterus resection rate of observation group was 0%, the control of the uterus resection rate was 9.38%, the team＇s uterus removal rate is lower than the control group（P〈0.05）, the difference was statistically significant. ConclusionHemabate combined with Iodoform gauze packing in uterine cavity in treating placenta previa effective prevention of cesarean delivery postpartum hemorrhage, high safety, worth clinical promotion.

关 键 词：卡前列素氨丁三醇注射液 剖宫产 碘仿纱条 前置胎盘 临床效果 

分 类 号：R969.4[医药卫生—药理学]