一种甚高频超声仿血液流速测量系统的实验研究  

An experimental study of a very high frequency ultrasonic simulated blood flow velocity measurement system

作　　者：王晓春[1] 周盛[1] 杨军[1] 邢维忠[1] 王效宁[1] 王延群[1] 计建军[1] WANG Xiao-chun,ZHOU Sheng,YANG Jun,XING Wei-zhong,WANG Xiao-ning,WANG Yan-qun,JI Jian-jun(Institute of Biomedical Engineering, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Tianjin 300192, Chin)

机构地区：[1]中国医学科学院.北京协和医学院生物医学工程研究所,天津300192

出　　处：《生物医学工程与临床》2018年第2期138-142,共5页Biomedical Engineering and Clinical Medicine

基　　金：国家自然科学基金青年项目(61601520);天津市科技计划项目(15JCZDJC327000);天津市科技计划项目(16YFZCSY00870);天津市科技计划项目(17YFZCSY00630);中国医学科学院医学与健康科技创新工程项目(2017-I2M-3-020)

摘　　要：目的设计并实现一种甚高频超声仿血液流速测量系统,用来完成模拟人体浅表器官血流信息实时检测的实验研究。方法笔者自制了血液仿体,该仿体由尼龙颗粒、纯净水、甘油、葡聚糖和非离子表面活性剂组成。该系统实验平台包含控制流速的医用注射泵、医用硅胶管和模拟血液仿体所组成的模拟血液循环系统;工作频率为50 MHz的单脉冲、机械、线性扫描探头;下位机超声回波信号采集电路和上位机模块构成的甚高频超声血流成像系统。将换能器置于模拟血管上方9 mm左右处,血液流动方向与探头扫查方向相向,调整注射泵的推动速度,得到焦点区域附近的模拟血液成像。结果笔者自制的血液仿体的声学特性在150 d内几乎没有改变,符合实验研究要求。由不同流速仿血流成像结果图可见,当流速较低时,红细胞成像颗粒较大,数量较少;当流速较高时,红细胞成像颗粒较小,数量较多。结论设计的甚高频超声仿血液流速测量系统可以初步得出模拟血流红细胞成像颗粒数值与模拟血流流速成正比,并由此判定血流流速的快慢。Objective To design and develop a kind of very high frequency simulated ultrasonic blood flow velocity measurement system, and perform the experimental study on real-time detection of simulated blood flow information of human superficial organs. Methods A self-made blood phantom was composed of nylon granules, pure water, glycerin, dextran and nonionic surfactant. The experimental platform was composed of medical injection pump, medical silicone tube and turbid liquid contained of nylon power, which formed simulated blood circulation system. The very high frequency ultrasonic blood imaging system was also composed of a single pulse, mechanical, linear scanning probe with working frequency of 50 MHz, an ultrasonic echo signal acquisition circuit of slave computer and a host computer. The transducer was put above the simulated vessel at about 9 mm. The direction of blood flow was at the same direction with scanning probe. The speed of injection pump was adjusted and then simulated blood images were obtained near focus area. Results The acoustic characteristics of self-made blood phantom remained no change in 150 days, which met the experimental research requirements. The results of simulated blood images with different flow rate showed that the erythrocyte granules were larger with small number at low flow rate, while erythrocyte granules were smaller with more number at high flow rate. Conclusion It is demonstrated that the very high frequency ultrasonic blood velocity measurement system preliminarily showed that the numerical results of simulated red blood cell imaging granules are proportional to simulated blood flow velocity, and thus the velocity of blood flow is determined.

关 键 词：甚高频 超声 血液流速 测量系统 浅表器官 

分 类 号：R318.04[医药卫生—生物医学工程]