睾丸生精功能与生殖激素水平、睾丸体积的相关性分析  

The correlation analysis of testicular sperm function with reproductive hormone level and testicular vol-

作　　者：张继跃[1] 仲纪祥[1] 左阳花[1] 邱峰龙[1] 苏静[1] 薛惠英[1] Zhang Jiyue, Zhong Jixiang, Zuo Yanghua，Qiu Fenglong, Su Jing, Xue Huiying(Reproductive Center of Huai＇an Maternal and Child Healthcare Hospital, Huai＇an 223002, Chin)

机构地区：[1]江苏省淮安市妇幼保健院生殖中心,淮安223002

出　　处：《中华内分泌外科杂志》2017年第6期517-520,共4页Chinese Journal of Endocrine Surgery

基　　金：江苏省中医药科技项目（YB2015128）

摘　　要：目的通过对无精子症患者进行睾丸穿刺取精和睾丸活检及检测血清生殖激素水平、睾丸体积，探讨睾丸生精功能与血清FSH、LH、INHB水平及睾丸体积的相关性。方法选取经精液离心沉渣镜检未见精子的无精子症患者为研究对象，共76例，采用化学发光法检测血清生殖激素水平，采用睾丸模型测量睾丸体积．并常规消毒进行睾丸穿刺取精。根据睾丸穿刺结果将其分为有精子组（A组）、无精子组（B组）；根据活检结果将其分为生精功能正常组（C组）、精子成熟阻滞组（D组）、生精功能低下组（E组）、唯支持细胞综合征组（F组）。同时，选择同期40例健康男性作为对照组（G组），对其进行精液常规、生殖激素水平及睾丸体积检查。结果A组、C组血清FSH、LH、INHB水平和睾丸体积与对照组相比，差异无统计学意义（P〉O．05）；B组、F组血清FSH、LH高于对照组，血清INHB水平、睾丸体积低于对照组，差异有统计学意义（P〈O．05）；E组血清FSH水平高于对照组，D组、E组血清INHB水平低于对照组，差异有统计学意义（P〈0．05）；采用Spearman相关分析表明，睾丸生精功能与血清FSH、LH水平呈负相关，与血清INHB水平、睾丸体积呈正相关（P〈0．05）。结论血清FSH、LH、INHB水平和睾丸体积的测定对预测无精子症患者睾丸生精功能有重要临床意义。为临床上睾丸穿刺取精提供参考依据。Objective Through testicular sperm aspiration （TESA）, testieular biopsy, and detection of serum reproductive hormone levels and testieular volume in azoospermia patients,to explore the correlation be- tween spermatogenie function of testis and serum FSH, LH, INHB levels, and testicular volume. Methods 76 cases of azoospermia patients were collected as the research objects. Chemiluminescence method was employed to detect the levels of serum reproductive hormone, and testis model was used to detect testieular volume. Routine disinfection was given to make TESA. According to TESA results,patients were divided into sperm group （group A）, and azoospermia group （group B）. According to testicular biopsy results,patients were divided into normal spermatogenic function group （group C ）, sperm maturation block group （group D）, permatogenic dysfunction group （group E）, and sertoli-cell-only syndrome group （group F）. At the same time,40 cases of healthy male were se- lected as the control group （group G）, and they received sperm routine examination, serum reproductive hormone and testicular volume detection. Results The level of serum FSH, LH, INHB and testicular volume in group A and C had no significant difference compared with that in group G（PM）.05）. The level of serum FSH and LH was significantly higher in group C than that in group G. The level of serum INHB and testicular volume was signifi- cantly lower than that in group G （P〈0.05）. The level of serum FSH in group E was higher than in group G. The level of serum INHB in group D and E was lower than that in group G, and the difference was statistically signifi- cant （P〈0.05）. Spearman correlation analysis showed that the spermatogenic function of testis was negatively cor- related with serum FSH and LH levels, and positively correlated with serum INHB level and testicular volume （P〈0.05）. Conclusion The detection of serum FSH, LH, INHB levels and testicular volume has important clini- cal value for predicting te

关 键 词：无精子症 生精功能 生殖激素水平 睾丸体积 

分 类 号：R698.2[医药卫生—泌尿科学]