中药对华法林药动学与药效学影响的研究  

Research on effects of traditional Chinese medicine on pharmacokinetics and pharmacodynamics of warfarin

作　　者：崔明宇[1] 李聪慧[1] 孔晓悦 张凯[1] 马英丽[1] CUI Ming-yu, LI Cong-hui, KONG Xiao-yue, ZHANG Kai, MA Ying-li(School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, Chin)

机构地区：[1]黑龙江中医药大学药学院,哈尔滨150040

出　　处：《哈尔滨商业大学学报（自然科学版）》2018年第1期5-7,15,共4页Journal of Harbin University of Commerce：Natural Sciences Edition

基　　金：黑龙江省自然科学基金项目(H2015044);国家自然科学基金项目(201281274034)

摘　　要：华法林为临床应用广泛的口服抗凝血药,治疗窗窄,易与药物发生相互作用而导致严重的不良反应.随着活血化瘀类中药在临床的广泛使用,越来越多的中药被发现对华法林药动学及药效学参数造成一定影响,对近五年中药与华法林相互作用进行综述,为临床合理用药提供参考.Warfarin is widely used as oral anticoagulant in clinical practice. It is easy to in- teract with the drug and cause serious adverse reactions. With the popularization of tradition- al Chinese medicine, more and more Chinese medicine has been found to have some effect on pharmacokinetic and pharmacodynamic parameters of warfarin. In this paper, the interac- tion between traditional Chinese medicine and warfarin in recent five years was reviewed, which provided the reference for clinical rational drug use.

关 键 词：华法林 中药 药动学 药效学 

分 类 号：R969[医药卫生—药理学]