Lifeceramics对大鼠慢性酒精性肝损伤的保护作用及机制  

The Protective effect of Lifeceramics on the liver of rats in chronic alcoholism

作　　者：马雪 李文喆 刘霞[1] 王思明[3] 李勇[3] 董玫[1] 铃木信夫 MA Xue , LI Wenzhe, LIU Xia, et al.(Department of Forensic Medicine, Hebei Medical University, Hebei Province, Shijiazhuang 050017, Chin)

机构地区：[1]河北医科大学法医学系,石家庄市050017 [2]日本千叶市千叶健康研究中心 [3]河北医科大学第四医院,石家庄市050011

出　　处：《临床合理用药杂志》2018年第7期40-42,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的研究Lifeceramics(LC)对大鼠慢性酒精性肝损伤的保护作用及作用机制。方法将SD大鼠随机分为4组:空白对照组、LC组、饮酒组以及LC+饮酒组。LC以5 mg/kg灌胃给予,其余受试物以10 ml/kg灌胃给予,每天1次,共90 d,建立大鼠慢性酒精性肝损伤模型,通过观察LC对大鼠慢性酒精性肝损伤的肝细胞病理改变、肝脏脂质过氧化反应和细胞炎性因子变化等影响,研究LC对大鼠慢性酒精性肝损伤的保护作用及作用机制。结果LC可以降低饮酒大鼠血清丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)活力,提高肝脏谷胱甘肽(GSH)含量,降低丙二醛(MDA)含量。病理切片观察表明饮酒组大鼠肝脏细胞以脂肪变性为主,部分肝脏可见肝细胞点状坏死,炎性细胞浸润,LC对饮酒大鼠肝脏病理改变有不同程度的作用。结论 LC对大鼠慢性肝损伤具有一定的保护作用,其作用机制可能与抗氧化作用以及抑制肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)等炎性因子有关。Objective To study the protective effect of Lifeceramics（ LC） on chronic alcoholism hepatic injury in rats and their mechanism. Methods Male SD rats were randomly divided into four groups： control groups,LC alone-administered,Alcohol（ liquor） alone-administered,liquor and LC-administered. The rats were administered with liquor and/or LC daily for 90 days. LC was given to rats by gavage with 5 mg/kg,and the rest of the subjects were given to rats by 10 ml/kg. At the end of the administration experiments,activities of ALT and AST in serum were estimated. The following examination was also performed in livers,estimation of the activities of GSH and SOD,and evaluation of the content of MDA and TG. Results LC could significantly reduce serum of ALT and AST in serum,MDA in livers,and Increase the content of GSH in liver. According to liver histopathological observation,livers in the liquor alone-administered group were dominated by steatosis,some livers suffered spoty necrosis and inflammatory cell lnfiltration. The liquor and LC-administered group showed different changes in pathologic changes in rat livers. Conclusion LC show specific protective effect on alcoholic hepatic injury. Its mechanism may be correlated with the inhibition of such inflammatory factors as TNF-α and IL-6.

关 键 词：Lifeceramics 酒精性肝损伤 抗氧化作用 抗炎活性 

分 类 号：R965[医药卫生—药理学]