胰岛素水平对缺血性心脏病死亡预测价值的多因素分析研究  

Multivariate Analysis of the Predictive Value of Fasting Insulin Level in the Death of Ischemic Heart Disease

作　　者：刘雪莲 张淑枝[1] LIU Xue- lian, ZHANG Shu- zhi(Department of Cardiology, Hengshui Halison International Peace Hospital, Hengshui 053000, Chin)

机构地区：[1]衡水市哈励逊国际和平医院心内科,河北衡水053000

出　　处：《标记免疫分析与临床》2018年第3期342-344,402,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的分析胰岛素水平对缺血性心脏病死亡的预测价值。方法研究选取非并发糖尿病的缺血性心脏病患者207例进行回顾性队列研究。随访3年,以确诊缺血性心脏病死亡为结局事件,并进行相关研究分析。应用SPSS 20.0统计软件包进行分析。结果本研究中基线数据显示暴露组患者BMI以及FBG水平与对照组的差异未见统计学意义;暴露组SBP和DBP水平则高于对照组,P<0.05;本研究中,暴露组随访病死率为9.68%;对照组检出2例,病死率为1.75%;暴露组随访病死率高于对照组,P<0.05;其中暴露组男性显著高于对照组,P<0.05;暴露组女性病死率为6.52%,对照组女性检出1例死亡病例,女性病死率为1.79%。Cox回归结果提示FINS增高、男性以及FBG和SBP异常增高与缺血性心脏病死亡结局正相关。结论提示FINS增高会增加缺血性心脏病患者死亡预后的发生风险,且男性也是独立危险因素之一,同时受到血压和血糖水平的影响,血压与血糖的异常增高状态也潜在增加死亡风险。Objective To analyze the predictive value of insulin level in the death of ischemic heart disease. Methods A retrospective cohort study was conducted in 207 patients with ischemic heart disease who were not concurrently diabetic. Followed up for 3 years to diagnose ischemic heart disease as the outcome of the incident among these patients, and related research and analysis was conducted. The SPSS 20.0 statistical software package was used for analysis. Results The baseline data showed that BMI levels and FBG levels in the exposed group were not statistically significant compared with the control group; SBP and DBP levels were higher in the exposed group than in the control group （ P 〈 0.05 ）. In this study, the follow- mortality rate in exposed group was 9.68% which is significantly higher than the control group, which is 1.75 % （ P 〈 0.05 ）. For male patients, the exposed group is significantlyhigher than the control group. For female patients, the mortality rate in the exposed group was 6.52. The mortality rate in the exposed group was higher than that in the control group （ P 〈 0.05 ）, The control group detected 1 case of female deaths, the mortality rate was 1.79%. Cox regression results suggested that FINS increased, male and FBG and SBP abnormalities and ischemic heart disease death outcome is positively correlated. Conclusion Increasing FINS increases the risk of death in patients with ischemic heart disease, and men are also independent risk factors, and are affected by blood pressure and blood glucose levels. Abnormal blood pressure and blood glucose levels also increase the risk of death.

关 键 词：空腹胰岛素水平 缺血性心脏病 死亡 预测 

分 类 号：R541[医药卫生—心血管疾病]