复发性流产的免疫学因素研究进展  

Process in immune etiology of recurrent spontaneous abortion

作　　者：秦诗 高玉平 Qin Shi;Gao Yuping(Department of Reproductive Center, Xinhua Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China （Qin S, Gao YP)

机构地区：[1]上海交通大学附属新华医院生殖中心,200092

出　　处：《中华生殖与避孕杂志》2018年第2期165-169,共5页Chinese Journal of Reproduction and Contraception

摘　　要：复发性流产(recurrent spontaneous abortion,RSA)是指连续≥2次的自然流产,且常发生于同一妊娠月份,临床发病率约1%~5%。除美国妇产科医师协会(ACOG)、皇家妇产科医师学会(RCOG)已明确提出的病因如染色体异常、母体生殖道异常、母体内分泌异常、生殖道感染、血栓形成倾向等,约80%与免疫因素相关。近年来研究者根据免疫学发病机制将RSA分为自身免疫型和同种免疫型两大类,前者可能由于自身抗体针对内皮细胞、滋养细胞及种植前胚胎导致妊娠失败,后者则可能与母-胎界面免疫失衡有关。本文将分别从这2个方面就RSA免疫学发病机制进行综述。Recurrent spontaneous abortion（RSA） is defined as two or more consecutive miscarriages generally occured in the same gestation period. It affects about 1%-5% of females at childbearing ages. Except for multiple causes for RSA been identified, such as chromosome abnormalities, maternal genital malformation, endocrine dysfunction, reproductive tract infections, thrombophilia, according to the American College of Obstetricians and Gynecologists（ACOG） and the Royal College of Obstetricians and Gynecologists（RCOG）, there are still 80% of risk factors related to immunology. Recently, RSA has been classified into two categories： autoimmune and alloimmune. Some autoantibodies may lead to pregnancy loss by targeting at vascular endothelial cells, trophoblastic cells and preimplantation embryos while alloimmune RSA may associate with the imbalance of immune interactions at the maternal-fetal interface. This article reviewed the two types of RSA respectively on the basis of immunological pathogenesis.

关 键 词：复发性流产(RSA) 免疫 病因 诊断 

分 类 号：R714.21[医药卫生—妇产科学]