肝脏不同类型细胞衰老对肝纤维化发生发展的影响  

Influence of different types of cell senescence on the development and progression of liver fibrosis

作　　者：郭珊 阳学风[1] GUO Shan, YANG Xuefeng.(Nanhua Hospital Affiliated to Nanhua University, Hengyang, Hunan 421000, Chin)

机构地区：[1]南华大学附属南华医院,湖南衡阳421000

出　　处：《临床肝胆病杂志》2018年第3期627-630,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金资助项目(81373465)

摘　　要：细胞衰老是细胞在受到某些特定刺激后而被激活的一种基本细胞应答程序,是生物机体的基本特征。肝纤维化是由各种致病因子所致肝内结缔组织异常增生,导致肝内弥漫性细胞外基质过度沉积的病理过程,可发展为肝硬化、肝癌。研究表明细胞衰老与肝纤维化的进展密切相关,针对肝内各种类型细胞衰老对肝纤维化的调控作用进行了综述。Cell senescence is a basic cell response triggered by various stimuli and is a basic characteristic of living organism. Liver fibrosis refers to the pathological process of diffuse excessive deposition of extracellular matrix in the liver caused by abnormal proliferation of connective tissue due to various pathogenic factors and can progress to liver cirrhosis and liver cancer. Studies have shown that cell senescence is closely associated with the progression of liver fibrosis. This article reviews the regulatory effect of different types of cell senescence on liver fibrosis.

关 键 词：肝硬化 细胞衰老 综述 

分 类 号：R575.2[医药卫生—消化系统]