柴胡加龙骨牡蛎汤对颞叶癫痫患者SOD、MDA的影响  

Effects of Chaihu-Longgu-Muli Decoction on the levels of blood superoxide dismutase and maiondiaidehyde in Temporal Lobe Epilepsy patients

作　　者：肖慧琼 杨萍 彭红莉 Xiao Huiqiong, Yang Ping, Peng Hongli(Department of Psychiatry, Brain Hospital of Hunan Province, College of Clinical Medicine, Hunan University of Chinese Medicine, Changsha 410007, Chin)

机构地区：[1]湖南省脑科医院精神科、湖南中医药大学临床医学院,长沙410007

出　　处：《中国医师杂志》2018年第3期357-359,363,共4页Journal of Chinese Physician

基　　金：国家自然科学基金(81603512);湖南省教育厅科研项目(15C1051);湖南省脑科医院院级课题(2017A04;2017B01)~~

摘　　要：目的探讨柴胡加龙骨牡蛎汤(CLMD)对颞叶癫痫患者超氧化物歧化酶(SOD)、丙二醛(MDA)的影响。方法将65例颞叶癫痫患者,按完全随机表法分成奥卡西平组(32例)、奥卡西平+CLMD组(33例),治疗28 d后,观察两组临床疗效、血清中SOD、MDA变化及不良反应。结果奥卡西平+CLMD组临床总有效率为87.8%,显著高于奥卡西平组53.1%,差异有统计学意义(P<0.05);两组治疗后SOD升高、MDA降低,与治疗前比较差异有统计学意义(P<0.05或P<0.01),且奥卡西平+CLMD组较奥卡西平组SOD升高、MDA降低(P<0.05或P<0.01);两组不良反应比较差异无统计学意义(P>0.05)。结论 CLMD对颞叶癫痫患者有明确治疗作用,安全性高,其机制可能与其增加SOD,降低MDA,抗氧化应激有关。Objective To investigate the effects of Chaihu-Longgu-Muli Decoction （CLMD） on superoxide dismutase （SOD） and maiondiaidehyde （MDA） in patients with temporal lobe epilepsy （TLE）. Methods 65 patients with TLE were randomly divided into Oxearbazepine group （n = 32 ） and Oxcarbazepine ＋ CLMD group （n = 33）. After 28 d, the curative effect, SOD, MDA changes in serum and side effect were observed between two groups. Results The clinical effective rate in Oxearbazepine ＋ CLMD group was 87.8% , slightly higher than that of the Oxcarbazepine group（53.1% ） （P 〈0. 05）. After treatment, serum SOD was significantly higher in the patients than before treatment in two groups, but serum MDA was significantly lower（ P 〈 0. 05 or P 〈 0. 01 ） , while the above changes were more obvious in the Oxcarbazepine ＋ CLMD group （P 〈 0. 05 ）. No statistically significant differences of side effect （ P 〉 0. 05 ）. Conclusions CLMD has higher curative effect with less side effect,which can lead to increase of the level of SOD and decrease of the level of MDA, and the mechanism is related to oxidative stress.

关 键 词：抗惊厥药/治疗应用 柴胡属/治疗应用 牡蛎科/治疗应用 癫痫 颞叶/中西医结合疗法/代谢 超氧化物歧化酶/代谢 丙二醛/代谢 

分 类 号：R277.7[医药卫生—中医学]