Targeting microthrombosis and neuroinflammation with vepoloxamer for therapeutic neuroprotection after traumatic brain injury  

作　　者：Ye Xiong Li Zhang Zheng Gang Zhang Asim Mahmood Michael Chopp 

机构地区：[1]Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, USA [2]Department of Neurology, Henry Ford Hospital, Detroit, MI, USA [3]Department of Physics, Oakland University, Rochester, MI, USA

出　　处：《Neural Regeneration Research》2018年第3期413-414,共2页中国神经再生研究（英文版）

摘　　要：Traumatic brain injury （TBI）： Despite improved supportive and rehabilitative care of TBI patients, TBI remains a leading cause of death and disability worldwide. To date, no effective pharmacological treatments are available for TBI. The mechanisms underlying brain damage and repair following TBI are complex and not completely understood. Coagulopathy after TBI is frequent and an independent prognostic factor for unfavorable outcome and prognosis （Stein and Smith, 2004）. It may be amenable to treatment, and effective management of coagulopathy may protect from secondary injury and poor outcomes. Although the main challenge for TBI management is to address the risk of hypocoagulopathy with prolonged bleeding and progression of hemorrhagic lesions, the risk of hypercoagulopathy with an increased microthrombosis formation warrants investigation to reduce neurological deficits after TBI.Traumatic brain injury （TBI）： Despite improved supportive and rehabilitative care of TBI patients, TBI remains a leading cause of death and disability worldwide. To date, no effective pharmacological treatments are available for TBI. The mechanisms underlying brain damage and repair following TBI are complex and not completely understood. Coagulopathy after TBI is frequent and an independent prognostic factor for unfavorable outcome and prognosis （Stein and Smith, 2004）. It may be amenable to treatment, and effective management of coagulopathy may protect from secondary injury and poor outcomes. Although the main challenge for TBI management is to address the risk of hypocoagulopathy with prolonged bleeding and progression of hemorrhagic lesions, the risk of hypercoagulopathy with an increased microthrombosis formation warrants investigation to reduce neurological deficits after TBI.

关 键 词：TBI Targeting microthrombosis and neuroinflammation with vepoloxamer for therapeutic neuroprotection after traumatic brain injury 

分 类 号：R651.15[医药卫生—外科学]