Immunomodulation as a neuroprotective strategy after spinal cord injury  

作　　者：Susana Monteiro António J. Salgado Nuno A. Silva 

机构地区：[1]Life and Health Sciences Research Institute(ICVS),School of Medicine,University of Minho,Campus de Gualtar,Braga,Portugal [2]ICVS/3B's-PT Government Associate Laboratory,Braga/Guimaraes,Portugal

出　　处：《Neural Regeneration Research》2018年第3期423-424,共2页中国神经再生研究（英文版）

基　　金：supported by Prémios Santa Casa Neurociências-Prize Meloe Castro for Spinal Cord Injury Research;Portuguese Foundation for Science and Technology(Financiado noambito do Projecto 3599-Promover a Producao Científica e Desenvolvimento Tecnológico e a Constituicao de Redes Temáticas(3599-PPCDT);project:PTDC/DTP-FTO/5109/2014;Post-Doctoral fellowship-SFRH/BPD/97701/2013-to N.A.Silva;IF Development Grant to A.J.Salgado

摘　　要：The initial trauma to the spinal cord is just the starting point for a cascade of endogenous events that will collectively determine the injury extension. These secondary events include, but are not limited to： glutamate excitoxicity, induction of apoptotic pathways, ionic imbalances and the development of a strong and dysfunctional inflammatory response. The secondary injury is associated to an aggravation of neuronal damage increasing the extent of neurological deficits （Ek et al., 2010）.The initial trauma to the spinal cord is just the starting point for a cascade of endogenous events that will collectively determine the injury extension. These secondary events include, but are not limited to： glutamate excitoxicity, induction of apoptotic pathways, ionic imbalances and the development of a strong and dysfunctional inflammatory response. The secondary injury is associated to an aggravation of neuronal damage increasing the extent of neurological deficits （Ek et al., 2010）.

关 键 词：Immunomodulation as a neuroprotective strategy after spinal cord injury SCI 

分 类 号：R651.2[医药卫生—外科学]