异丙嗪麻黄碱合剂在模拟失重大鼠体内的药动学研究  

Pharmacokinetic Study of Promethazine and Ephedrine Combination in Rats Under the Simulated Microgravity Condition

作　　者：甘琳[1,2] 郑志芬 王鲁君[3] 邓玉林[1] 李玉娟[1] GAN Lin1,2 , ZHENG Zhi-fen1 , WANG Lu-juna , DENG Yu-lin1, LI Yu-juan1(1. School of Life Science, Beijing Institute of Technology, Beijing 100081, China; 2. Applied Analytical Chemistry, University of Duisburg-Essen, Essen, Germany, 45141~ 3. Department of Pharmacy, General Hospital of Chinese Armed Police, Beijing 100039, Chin)

机构地区：[1]北京理工大学生命学院,北京100081 [2]德国杜伊斯堡-埃森大学应用分析化学研究所,德国45141 [3]中国武警总医院药剂科,北京100039

出　　处：《北京理工大学学报》2018年第2期216-220,共5页Transactions of Beijing Institute of Technology

基　　金：国家重大科学仪器设备开发专项基金资助项目(2012YQ12004410;2012YQ04014010);北京理工大学校内基础基金资助项目(20131642004)

摘　　要：分别对不同模拟失重周期大鼠,展开给药异丙嗪和麻黄碱合剂的药物动力学研究,获取不同模拟失重时间点下两种药物的药物动力学参数,为保障航天员合理、安全用药提供基础研究数据.采用大鼠尾悬吊模型模拟失重,建立LC-MS/MS法测定大鼠血浆中异丙嗪和麻黄碱浓度,并求算各组中两种药物的动力学参数.与对照组相比,异丙嗪和麻黄碱在不同吊尾组药时曲线下面积(A_(UC0-t)),血药峰浓度(C_(max)),消除速率常数(K_e值),血浆半衰期(T_(1/2))均有变化.不同模拟失重周期对异丙嗪和麻黄碱在大鼠体内的药动学过程产生显著影响.To provide basic research data for astronauts to take medicine reasonably and safely,some pharmacokinetic studies on promethazine and ephedrine were carried out in rats＇ plasma to obtain the pharmacokinetic parameters in different simulated weightlessness periods.A rat tailsuspension model was used to simulate weightlessness,and an HPLC-MS/MS method was developed to determine the promethazine and ephedrine quantification in rat plasma.The pharmacokinetic parameters in simulated weightless group show the differences between control and model groups,such as the area under the concentration-time curve（A_（UC0-t））,peak plasma concentration（C_（max））,elimination rate constant K_e and half-life（T_（1/2））.Different simulated weightlessness periods have a significant impact on the pharmacokinetic process of drugs in rats.

关 键 词：异丙嗪 麻黄碱 模拟失重 药物动力学 

分 类 号：V211[航空宇航科学与技术—航空宇航推进理论与工程]