胶原诱导性关节炎大鼠^(18)F-NaF micro-PET/CT和μCT评分与组织病理学的相关性分析  

Correlation of ^(18)F-NaF micro-PET/CT and μCT score with histopathology in collagen-induced arthritis rats

作　　者：黄禾 卢苇[1] 刘勤[1] 曾一飞 邹同恩[1] 陈跃 HUANG He1, LU Wei1, LIU Qin1, ZENG Yi fei1, ZOU Tongen1 , CHEN Yue2(1. Department of Nuclear Medicine, Luzhou People＇s Hospital, Luzhou 646000, China ; 2. Department of Nuclear Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, Chin)

机构地区：[1]泸州市人民医院核医学科,四川泸州646000 [2]西南医科大学附属医院核医学科,四川泸州646000

出　　处：《中国介入影像与治疗学》2018年第4期238-242,共5页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的评价胶原诱导性关节炎(CIA)大鼠^(18)F-NaF micro-PET/CT和μCT评分与组织病理学的相关性。方法选取70只健康雌性SD大鼠,随机取其中20只为对照组,50只为模型组,分别在造模成功后10天行micro-PET/CT显像,测定PET显像最小标准化摄取值(SUV_(min))、最大标准化摄取值(SUV_(max))及平均标准化摄取值(SUV_(mean))值;随后进行μCT扫描并评分,通过组织病理学评分评估类风湿性关节炎严重程度。对SUV_(min)、SUV_(max)及SUV_(mean)值、μCT评分与组织病理学评分进行Pearson相关分析。结果 ^(18 )F-NaF PET/CT的SUV_(min)、SUV_(max)、SUV_(mean)、μCT评分与组织病理学评分均呈正相关(r=0.920、0.943、0.923、0.768,P均<0.001)。结论 ^(18 )F-NaF Micro-PET/CT能可靠地定量评价大鼠CIA模型骨侵蚀和骨畸形,优于μCT检查。Objective To explore the correlation between 18F-NaF micro-PET/CT, μCT score and histopathology of collagen-induced arthritis （CIA） rats. Methods Seventy healthy female SD rats were randomized into CIA group （n=50） and control group （n=20）. Micro-PET/CT imaging was performed 10 days after successful modeling. Minimum standardized uptake value （SUVmin）, maximum standardized uptake value （SUVmax）, mean standardized uptake value （SUVmean） and μCT score were measured, and the severity of rheumatoid arthritis was assessed with histopathology. The correlations between SUVmin, SUVmax, SUVmean, μCT score and histopathology of CIA were analyzed. Results SUVmin, SUVmax, SUVmean, μCT score of CIA all showed positive correlations with histopathology （r=0.920, 0.943, 0.923, 0.768, all P〈0.001）. Conclusion 18F-NaF micro-PET/CT is a quantitative imaging method for evaluating bone erosion and bone malformation in rat rheumatoid arthritis models of CIA, which is superior to μCT examination.

关 键 词：关节炎 类风湿 放射性核素显像 体层摄影术 发射型计算机 大鼠 

分 类 号：R332[医药卫生—人体生理学] R817.4[医药卫生—基础医学]