多样本光学相干血流运动造影技术及应用  

Mass Sample Optical Coherence Tomography Angiography Technology and Application

作　　者：李培[1] 李鹏[1] Li Pei, Li Peng(State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering Zhejiang University, Hangzhou, Zhejiang 310027, Chin)

机构地区：[1]浙江大学光电科学与工程学院现代光学仪器国家重点实验室,浙江杭州310027

出　　处：《中国激光》2018年第3期1-11,共11页Chinese Journal of Lasers

基　　金：国家973计划(2015AA020515);国家自然科学基金(61475143;11404285;61335003;61327007);浙江省科技厅公益技术研究社会发展项目(2015C33108);中央高校基本科研业务费专项资金(2017QNA5004);教育部留学回国人员科研启动基金

摘　　要：血流是衡量机体生理功能和病理状态的重要指标,血流检测需要一种有效的、活体、无标记、毛细血管水平的三维血流灌注成像手段。光学相干血流运动造影(OCTA)技术将血红细胞与周围组织的相对运动作为内源性的血流标记特征,取代常规外源性的荧光标记物。综合利用光学低相干技术的空间散射信号收集能力以及动态光学散射技术的运动识别能力,在三维空间中识别动态血流区域,剔除静态周围组织,实现一种活体、无标记、三维光学血流运动造影,快速获取毛细血管水平的血流灌注形态结构与生理功能信息。针对多样本OCTA技术进行了系统性的回顾,主要包括无标记血流造影的运动对比度机制,微小血流运动高灵敏度检测方法,独立多样本的高效并行采集策略,以及该技术在脑皮层血流成像中的应用研究。Blood flow is the vital indicator to measure the body′s physiological functions and pathological condition. Blood flow testing requires an effective, live, unmarked, capillary level three-dimensional blood flow perfusion weighted imaging approach. Optical coherence tomography angiography （OCTA） technique uses the relative motion of red blood cells and the surrounding tissue as an endogenous marker of blood flow to replace conventional exogenous fluorescent markers. The spatial scattering signal acquisition capability of the optical low-coherence and the motion recognition capabilities of the dynamic optical scattering technology are comprehensively utilized to identify dynamic blood flow area in three-dimensional space, exclude the static surrounding tissue, achieve a living, unmarked, three-dimensional optical blood flow angiography, and obtain capillary blood flow perfusion morphology structure and physiological function information of the capillary level rapidly. This paper systematically reviews the mass sample OCTA technique that primarily includes the motion contrast mechanism of unmarked blood flow angiography, a detection method for high-sensitive tiny blood flow motion, an effective strategy for parallel acquisition of independent mass samples, and the application research of this technique on cortex blood flow imaging.

关 键 词：医用光学 光学相干层析 微血管造影 运动对比 

分 类 号：TN247[电子电信—物理电子学]