数据挖掘难治性肾病综合征中医证候规律及用药特点  

Laws of TCM Syndromes of Refractory Nephrotic Syndrome and Characteristics of Chinese Medicinal Herbs Used :A Data Mining Based on Literature

作　　者：张毅[1] 孙升云[1] 李松青[1] 李丽洁 唐世红 ZHANG Yi, SUN Shengyun, LI Songqing, LI Lijie, TANG Shihong(Jinan University, Guangzhou 510630, Guangdong, China)

机构地区：[1]暨南大学

出　　处：《辽宁中医药大学学报》2018年第3期149-153,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：广东省科技计划项目(2014A020221015);广东省中医药局科研项目(20171075)

摘　　要：目的：采用数据挖掘技术探讨难治性肾病综合征（RNS）的中医证候规律及中医用药特点。方法：检索2007年1月—2016年12月中国知网、维普、万方数据库中有关RNS中医证候及治疗的临床研究文献。对纳入文献进行数据提取,对证型、中药进行频数分析,对常见证型与中药、中药与中药之间进行关联规则分析。结果：纳入149篇文献中共涉及39种证型,共333频次,其中虚证18种,实证12种,虚实夹杂9种。39种证型以脾肾阳虚证、湿热证、气阴两虚证、血瘀证、阴虚火旺证5种证型最为多见;经关联规则分析得出了与常见证型关联性较强的中药。纳入文献使用处方共247张,涉及中药197味,共3207频次,涉及19个类别,以补虚药、清热药、利水渗湿药、活血化瘀药、收涩药为主;经关联规则分析得出了临床治疗RNS的常用中药配伍。结论：RNS虚证以脾肾阳虚多见,实证以湿热多见;临床上多以补气药、利水消肿药、固精缩尿止带药、清热凉血药及活血化瘀药之间的配伍治疗RNS。Objective：To reveal the rules of TCM syndromes and prescription of refractory nephrotic syndrome（RNS）by using data mining methods. Methods：After retrieving clinical trials of CNKI,VIP and Wan Fang database related to TCM treatment and syndromes of RNS,besides manual searching from 2007 to 2016,the database was established. The data included in the literature were extracted,the frequency of syndromes and traditional Chinese medicines were analyzed,and association rules between common syndromes and traditional Chinese medicine,traditional Chinese medicine and traditional Chinese medicine were analyzed. Results：The 149 references involved 39 syndrome patterns,which included 18 deficiency syndromes,12 excess syndromes and 9 deficiency complicated with excess syndromes. And the total frequency of the syndrome patterns was 333. The top 5 high-frequency syndrome patterns were Yang deficiency of spleen and kidney syndrome,damp-heat syndrome,deficiency of both Qi and Yin syndrome,blood stasis syndrome,and Yin-deficiency and fire-hyperactivity syndrome. And the TCM of strong correlation with these syndromes was obtained according to the analysis of association rules. There were 197 herbs in 247 prescriptions of standard literatures. And the total frequency of the herbs was 3207,involving 19 categories. Drugs that mostly used in the treatment of RNS were those to reinforce deficiency,clear heat,clearing dampness and promote diuresis,promote blood circulation,and astringent medicine. According to the analysis of association rules,the compatibility of herbs in treatment of RNS was obtained. Conclusion：The deficiency syndrome was frequently seen with yang deficiency of spleen and kidney syndrome,and damp-heat syndrome was frequently seen in the excess syndrome. In clinical,RNS was treated by the compatibility of Qi-tonifying herb,promoting diuresis and detumescence herb,astringent medicine,heatclearing herb,and promote blood circulation drug.

关 键 词：难治性肾病综合征 中医证候 用药特点 数据挖掘 关联分析 

分 类 号：R692[医药卫生—泌尿科学]