孕晚期不同粒径颗粒物暴露对胎儿生长的影响  

The association between exposure to different sizes of particulate matter and fetal growth in late pregnancy

作　　者：尤博宁 岳玎利[2] 戴佳佳[1] 林薇薇 曾晓凌 麦慧映 胡前胜[1] YOU Bo-ning1, YUE Ding-li2, DAI Jia-jia1, LIN Wei-wei1, ZENG Xiao-ling3, MAI Hui-ying3, HU Qian-sheng1(1.Department of Environmental and Occupational Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510080 ; 2.Environmental Monitoring Center of Guangdong Province, National Environmental Protection Zone Air Quality Monitoring Key Laboratory, Guangzhou, Guangdong 510000 ;3.Maternal and Child Health Hospital of Heshan, Guangdong 529700, China)

机构地区：[1]中山大学公共卫生学院,广东广州510080 [2]广东省环境监测中心,国家环境保护区域空气质量监测重点实验室,广东广州510000 [3]鹤山市妇幼保健计划生育服务中心,广东广州529700

出　　处：《热带医学杂志》2018年第3期316-320,共5页Journal of Tropical Medicine

基　　金：广东省自然科学基金(2016A030313194);中山大学青年教师培育项目(16ykpy18)

摘　　要：目的分析妊娠期不同粒径大气颗粒物(PM)暴露对胎儿生长的影响。方法收集2014年11月至2016年12月广东省鹤山市妇幼保健院胎儿的孕晚期超声资料、鹤山市不同粒径大气颗粒物资料,采用多重线性回归模型研究大气颗粒物暴露对胎儿生长参数如双顶径(BPD)、头围(HC)、腹围(AC)、股骨长(FL)、估计胎儿体重(EFW)的影响。结果在控制孕妇年龄、产次、气象因素等因素后,B超前1个月,PM_(10)每升高10μg/m^3,胎儿FL下降0.167 mm(95%CI:-0.329^-0.005),PM_(2.5)每升高10μg/m^3,胎儿FL下降0.101 mm(95%CI:-0.196^-0.006);B超前2个月,PM_(10)每升高10μg/m^3,胎儿AC下降1.399 mm(95%CI:-2.401^-0.397),胎儿FL下降0.276 mm(95%CI:-0.469^-0.082),PM_(2.5)每升高10μg/m^3,胎儿FL下降0.122 mm(95%CI:-0.240^-0.005)。B超前3个月,PM_(10)每升高10μg/m^3,胎儿AC下降1.940 mm(95%CI:-3.055^-0.826),胎儿FL下降0.272 mm(95%CI:-0.476^-0.067)),PM_(2.5)每升高10μg/m^3,胎儿HC下降1.502 mm(95%CI:-2.682^-0.323)。结论妊娠期妇女孕晚期暴露于不同粒径的大气颗粒物,可能会导致胎儿生长发育受限。Objective To evaluate the fetal growth changes that were impacted by the exposure to different sizes paniculate matter （PM）. Methods The ultrasound results in late pregnancy from Maternal and Child Health Hospital and the atmospheric information of different sizes paniculate matter of Heshan were collected during November 2014 and December 2016. Multiple linear regression analysis was applied to evaluate the impacts of the atmospheric particle exposure to fetal growth [ biparietal diameter （ BPD ） , head circumference （ HC ） , abdominal circumference （ AC ） , femur length （FL） , and estimated fetal weight （EFW） ]. Results After adjustment for the influence of maternal age, parity, meteorological factors, during the prior 1 month of ultrasound examination, with a 10 μg/m3 increase in PM10, the fetal femur length was decreased by -0.167 mm （95%CI： -0.329--0.005） , with a 10 μg/m3 increase in PM25, the fetal FL was decreased by-0.101 mm （95%CI： -0.196, -0.006）. During the prior 2 months of ultrasound examination, with a 10 μg/m3 increase in PM10, the fetal abdominal circumference was decreased by -1.399 mm （95%CI： -2.401-0.397 ） , the fetal FL was decreased by-0.276 mm （95%CI： -0.469--0.082） , with a 10 μg/m3 increase in PM2.5, the fetal femur length was decreased by -0.276 mm （95%CI： -0.469^-0.082）. During the prior 3 months of ultrasound examination, with a 10 μg/m3 increase in PM10, the fetal AC was decreased by-1.940 mm （95%CI： -3.055--0.826） , the fetal femur length was decreased by -0.272 mm （95%CI： -0.476--0.067）, with a 10 μg/m3 increase in PM：s, the fetal head circumference was decreased by -1.502 mm （ 95%CI ： -2.682--0.323 ）. Conclusion Exposure to different sizes of particulate matter in late pregnancy could lead to restricted fetal growth.

关 键 词：大气污染 可吸入颗粒物 细颗粒物 可入肺颗粒物 胎儿生长 

分 类 号：R181.34[医药卫生—流行病学]