生长停滞和DNA损伤诱导蛋白45α在肝再生及肝病中的研究进展  

Research progress of growth arrest and DNA damage inducible 45α in liver regeneration and liver diseases

作　　者：杨献光[1,2] 李帅洪 和春翠 夏聪 朱琳[1] 赵卫明[1,2] 徐存拴 YANG Xian-guang;LI Shuai-hong;HE Chun-cui;XIA Cong;ZHU Lin;ZHAO Wei-ming;XU Cun-shuan(1. College of Life Science, He＇ nan Normal University, He＇ nan Xinniang 453007, China; 2. State Key Laboratory Cultivation Base for Cell Differentiation Regulation, He＇ nan Normal University, He＇ nan Xinxiang 453007, Chin)

机构地区：[1]河南师范大学生命科学学院,河南新乡453007 [2]河南省一科技部共建细胞分化国家重点实验室培育基地,河南新乡453007

出　　处：《解剖学报》2018年第2期268-272,共5页Acta Anatomica Sinica

基　　金：国家自然科学基金(U1404312); 河南省科技攻关项目(172102310507); 河南师范大学博士启动基金; 青年骨干教师项目(2014)

摘　　要：生长停滞和DNA损伤诱导蛋白45α(GADD45α)是一种应激诱导蛋白,它可诱导Gadd45α基因的表达。GADD45α在再生肝及肝硬化、肝癌、肝衰竭等肝病中表达显著上调,与多种肝病发生发展及预后密切相关。GADD45α蛋白通过与其他蛋白相互作用,在调控细胞周期、维持基因组稳定、诱导细胞凋亡等方面发挥重要作用。以下我们综述了GADD45α与肝再生关系的研究进展,为进一步了解肝再生与肝脏疾病的发生机制以及治疗和预防肝病奠定基础。The growth arrest and DNA damage inducible 45 alpha（ GADD45α） is a stress-inducible protein.Variety of stress can induce the expression of growth arrest and DNA damage inducible 45 alpha（ Gadd45α） gene. Gadd45αhas been found to be abundantly expressed in various liver diseases,and be closely related to the development and prognosis of liver cancer,liver fibrosis and fatty liver. GADD45α protein plays an important role in regulating cell cycle,maintaining genome stability,and inducing apoptosis by interacting with other proteins. This review summarizes the progress of liver regeneration and GADD45α,and could lay a foundation for further understanding of the mechanism of liver regeneration and liver diseases,and for the treatment and prevention of liver diseases.

关 键 词：肝再生 生长停滞和DNA损伤诱导蛋白45α DNA损伤修复 细胞增殖 

分 类 号：Q28[生物学—细胞生物学]