滤泡辅助性T细胞及其功能分子在系统性红斑狼疮中的研究进展  

Follicular helper T cells in systemic lupus erythematosus： a review

作　　者：黄子宸 赵铖[1] 王健[1] 郑乐婷[1] Huang Zichen, Zhao Cheng, Wang Jian, Zheng Leting(Department of Rheumatology and Immunology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Chin)

机构地区：[1]广西医科大学第一附属医院风湿免疫科,南宁530021

出　　处：《中华微生物学和免疫学杂志》2018年第1期73-78,共6页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金（81660275）;广西医科大学青年科学基金（GxMuYsF201335）;广西高等学校科学研究项目（KY2015LX062）

摘　　要：系统性红斑狼疮（systemic lupus erythematosus，SLE）是一种以B细胞过度活化产生大量抗体为特征的系统性自身免疫病。抑制抗体产生可控制SLE病情，研究B细胞分化过程的影响因素可为治疗提供新方向。滤泡辅助性T细胞（follicular helper T cell, Tfh）是B细胞产生抗体的主要辅助细胞，在SLE发病机制中扮演重要角色。本文总结Tfh细胞中重要调控作用分子及其在SLE中的病理作用，为SLE的诊断与治疗提供新的策略与方法。Systemic lupus erythematosus （SLE） is a severe systemic autoimmune disease, which is characterized by excessive production of autoantibodies caused by B cell hyperactivity. Thus, reducing au- toantibody production can control the development of SLE, and understanding the molecular and cellular fac- tors involved in the differentiation of B cells will provide new therapeutic targets. Follicular helper T cells （Tfh） are defined as a new subset of CD4＋ T cells specialized in providing help to B cells, which is suspec- ted to play a critical role in the pathogenesis of SLE. In the present review, we give an overview of key mole cules involved in the differentiation, regulation and functions of Tfh, discuss the roles of Tfh in SLE and de- scribe some potential therapeutic targets for SLE.

关 键 词：系统性红斑狼疮 滤泡辅助性T细胞 发病机制 治疗 

分 类 号：R593.241[医药卫生—内科学]